Cefradine
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| Image:Cefradine.svg | |
| Cefradine
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| Systematic (IUPAC) name | |
| (6R,7R)-7-{[(2R)-2-amino-2-(1-cyclohexa-1,4- dienyl)acetyl]amino}-3-methyl-8-oxo-5-thia- 1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | |
| Identifiers | |
| CAS number | |
| ATC code | J01 |
| PubChem | |
| Chemical data | |
| Formula | C16H19N3O4S |
| Mol. mass | 349.406 g/mol |
| Pharmacokinetic data | |
| Bioavailability | Well absorbed |
| Protein binding | <10% |
| Metabolism | Nil |
| Half life | 0.9 hours |
| Excretion | Renal, unchanged |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
℞ Prescription only |
| Routes | Oral, IM, IV |
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Cefradine (INN) or cephradine (former BAN) is a first generation cephalosporin antibiotic.
Indications
It has similar spectrum of activity to cefalexin.
Dosage
Dosage by mouth for adults is 250–500 mg every 6 hours, or 500 mg to 1 g every 12 hours. In severe infections up to 1 g every 6 hours may be used. Dosages for children are based upon their weight with 25–50 mg/kg total daily dose given in 2–4 divided doses.
Formulations
Caspules containing 250 mg or 500 mg, Syrup containing 250 mg/5 ml, or vials for injection containing 500 mg or 1 g.
References
- British National Formulary 45 March 2003
Antibacterials for systemic use: beta-lactam antibiotics - cephalosporins and related (J01D) | |
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| First generation | Cefacetrile, Cefadroxil, Cefalexin, Cefaloglycin, Cefaloridine, Cefalotin, Cefapirin, Cefatrizine, Cefazedone, Cefazolin, Cefradine, Cefroxadine, Ceftezole |
| Second generation | Cefaclor, Cefamandole, Cefmetazole, Cefonicid, Ceforanide, Cefotiam, Cefprozil, Cefuroxime |
| Third generation | Cefdinir, Cefditoren, Cefetamet, Cefixime, Cefmenoxime, Cefodizime, Cefoperazone, Cefotaxime, Cefpiramide, Cefpodoxime, Cefsulodin, Ceftazidime, Ceftibuten, Ceftizoxime, Ceftriaxone, Latamoxef |
| Fourth generation | Cefepime, Cefpirome, Cefquinome |
| Fifth generation | Ceftobiprole |
| Other beta-lactam antibacterials | Monobactams (Aztreonam), Carbapenems (Parenteral - Meropenem, Ertapenem, Imipenem, Doripenem, Oral - Faropenem) |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
