Ceragenin
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Ceragenins, or cationic steroid antibiotics (CSAs), are synthetically produced small molecule chemical compounds comprised of a sterol backbone with amino acids and other chemical groups attached to them. These compounds have a net positive charge that is electrostatically attracted to the negatively charged cell membranes of certain viruses, fungi and bacteria. CSAs have a high binding affinity for such membranes (including Lipid A[1]) and are able to rapidly disrupt the target membranes leading to rapid cell death. While CSAs have a mechanism of action that is also seen in antimicrobial peptides, which form part of the body's innate immune system, they avoid many of the difficulties associated with their use as medicines.[1]
Ceragenins were invented by Dr. Paul B. Savage of Brigham Young University's Department of Chemistry and Biochemistry and exclusively licensed to Ceragenix.[1] In data previously presented by Dr. Savage and other researchers, CSAs have been shown to have broad spectrum antibacterial activity.[1] Dr. Derya Unutmaz, Associate Professor of Microbiology and Immunology at the Vanderbilt University School of Medicine, tested several CSAs in his laboratory for their ability to kill HIV directly. According to Unutmaz, "We have some preliminary but very exciting results. But we would like to formally show this before making any claims that would cause unwanted hype."[1]
On February 6, 2006, researchers (including Dr. Paul B. Savage) announced that a Ceragenin compound, CSA-54, appears to inactivate HIV. This conclusion is still awaiting peer review.[1]
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
