Ceramide kinase
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In enzymology, a ceramide kinase (EC 2.7.1.138) is an enzyme that catalyzes the chemical reaction
- ATP + ceramide
ADP + ceramide 1-phosphate
Thus, the two substrates of this enzyme are ATP and ceramide, whereas its two products are ADP and ceramide 1-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:ceramide 1-phosphotransferase. This enzyme is also called acylsphingosine kinase. This enzyme participates in sphingolipid metabolism.
References
- IUBMB entry for 2.7.1.138
- BRENDA references for 2.7.1.138 (Recommended.)
- PubMed references for 2.7.1.138
- PubMed Central references for 2.7.1.138
- Google Scholar references for 2.7.1.138
- Bajjalieh SM, Martin TF, Floor E (1989). "Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles". J. Biol. Chem. 264: 14354–60. PMID 2547795.
External links
- The CAS registry number for this enzyme class is 123175-68-8.
Gene Ontology (GO) codes
Acknowledgement and Attribution Regarding Sources of Content
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