Cetirizine pharmacokinetics and molecular data

You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-525-6884

List of indications

Absorption

Distribution

Metabolism

Elimination

---

Absorption

The bioavailability of cetirizine hydrochloride from ZYRTEC-D 12 HOUR Extended Release Tablets is not significantly different from that achieved with separate administration of a cetirizine 5 mg tablet.Return to top

Food interaction

Food had no significant effect on the extent of cetirizine absorption (AUC), but Tmax was delayed by 1.8 hours and Cmax was decreased by 30%.Return to top

Distribution

The mean plasma protein binding of cetirizine is 93%, independent of concentration in the range of 25-1000 ng/mL, which includes the therapeutic plasma levels observed. No plasma protein binding data in humans are available.Return to top

Metabolism

Cetirizine is metabolized to a limited extent by oxidative O-dealkylation to a metabolite with negligible antihistaminic activity. The enzyme or enzymes responsible for this metabolism have not been identified.Return to top

Elimination

After administration of the ZYRTEC-D 12 HOUR Extended Release Tablet, the mean elimination half-life of cetirizine was 7.9 hours.Return to top

---

The content of this page is taken from the FDA package insert for this drug and should not be edited.