Cetylpyridinium chloride
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| Cetylpyridinium chloride | |
|---|---|
| |
| IUPAC name | 1-Hexadecylpyridinium chloride |
| Identifiers | |
| CAS number | |
| PubChem | |
| SMILES | CCCCCCCCCCCCCCCC[n+]1ccccc1.[Cl-] |
| Properties | |
| Molecular formula | C21H38NCl |
| Molar mass | 339.986 g/mol |
| Melting point |
77 °C, 350 K, 171 °F |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references | |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-525-6884
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch. Cetylpyridinium chloride (CPC) is a cationic quaternary ammonium compound in some types of mouthwashes, toothpastes, lozenges, throat sprays, anti-snore throat sprays, breath sprays, and nasal sprays. It is an antiseptic that kills bacteria and other microorganisms. It has been shown to be effective in preventing dental plaque and reducing gingivitis. It has also been used as an ingredient in certain pesticides. However, this ingredient has also been shown (according to WebMD,[1] eMedicine,[1] and Amazon.com[1] and Drugstore.com reviews of Crest Pro-Health® rinse product) to cause brown stains between the teeth.
Synonyms
Cetylpyridinium chloride is called or is present in commercial products such as n as 1-palmitylpyridinium chloride, C16-alkylpyridinium chloride, 1-hexadecylpyridinium chloride, acetoquat CPC, aktivex, ammonyx CPC, cecure, ceepryn chloride, cepacol, ceprim, cepacol chloride, cetafilm, cetamium, dobendan, halset, ipanol, medilave, mercocet, merothol, pionin B, pristacin, pyrisept and asept.
Physical and chemical properties
Cetylpyridinium chloride has the molecular formula C21H38NCl and at its pure form is in a solid state at room temperature. It has a melting point of 77 °C when anhydrous or 80–83 °C in its monohydrate form. It is insoluble in acetone, acetic acid, or ethanol. It has a pyridine-like odor. It is combustible. Concentrated solutions are destructive to mucous membranes. It is very toxic when inhaled.
The CAS number for the monohydrate is [].
In some products, cetylpyridinium bromide is used instead. Its properties are virtually identical.
Toxicology and Pharmacology
The LD50 in rats is 200 mg/kg.
References
External links
- Material Safety Data Sheet
- Page on its use in mouthwash
- Chemical Information
- An in vitro evaluation of the availability of cetylpyridinium chloride and chlorhexidine in some commercially available mouthrinse products by S. Sheen and M. Addy in British Dental Journal
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
