Chinese hamster ovary cell

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Chinese Hamster Ovary cells (CHO cells) are a cell line derived from Chinese Hamster ovary cells. They are often used in biological and medical research. They were introduced in the 1960s and are used in a cultured monolayer in culture flasks. They require the amino acid proline in their culture medium; this property makes them ideal for genetics research.^{[citation needed]} CHO cells are used in studies of genetics, toxicity screening, nutrition and gene expression particularly expression of recombinant proteins.

See also

• Cell culture
• Drug development
• Pre-clinical development
• Caco-2

References

Tjio J. H., Puck T. T., Genetics of somatic mammalian cells. II. chromosomal constitution of cells intissue culture. J. Exp. Med. 1958; 108: 259-271.

External links

• Phase contrast images of CHO cells
• Article from 1958 on culturing euploid cells
• http://www.biotech.ist.unige.it/cldb/cl721.html

de:CHO-Zellen