Chloramphenicol acetyltransferase
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| Image:Chloramphenicol acetyltransferase 3CLA transparent.png | |
| Ribbon diagram of the chloramphenicol acetyltransferase trimer with chloramphenicol bound. From PDB 3CLA. | |
| chloramphenicol acetyltransferase
| |
| Identifiers | |
| Symbol | CAT |
| UniProt | P62577 |
| Other data | |
| EC number | 2.3.1.28 |
Chloramphenicol acetyltransferase is a bacterial enzyme that detoxifies the antibiotic chloramphenicol. It is responsible for chloramphenicol resistance in bacteria. This enzyme covalently attaches an acetyl group from acetyl-CoA to the chloramphenicol molecule so that it is unable to bind to the ribosome.
Transferases: acyltransferases (EC 2.3) | |
|---|---|
| 2.3.1: other than amino-acyl groups (mostly acetyltransferases) | N-Acetylglutamate synthase - Choline acetyltransferase - Acetyl-Coenzyme A acetyltransferase - Dihydrolipoyl transacetylase - Acetyl-CoA C-acyltransferase - Beta-galactoside transacetylase - Carnitine O-palmitoyltransferase (CPT1, CPT2) - Acyltransferase like 2 - Chloramphenicol acetyltransferase - Aminolevulinic acid synthase - Beta-ketoacyl-ACP synthase - Glyceronephosphate O-acyltransferase - Lecithin-cholesterol acyltransferase - Histone acetyltransferase (P300/CBP) - Serotonin N-acetyl transferase |
| 2.3.2 - Aminoacyltransferases | Gamma glutamyl transpeptidase - Peptidyl transferase - Transglutaminase (Tissue transglutaminase, Keratinocyte transglutaminase, Factor XIII) |
| 2.3.3 - converted into alkyl on transfer | Citrate synthase - ATP citrate lyase - HMG-CoA synthase |
