Cholinergic

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Overview

A synapse is cholinergic if it uses acetylcholine as its neurotransmitter.

Cholinergic means "related to the neurotransmitter acetylcholine," and is typically used in a neurological perspective. The parasympathetic nervous system is entirely cholinergic. Neuromuscular junctions, preganglionic neurons of the sympathetic nervous system, the basal forebrain, and brain stem complexes are also cholinergic.

A substance is cholinergic if it is capable of producing, altering, or releasing acetylcholine ("indirect-acting") or mimicking its behaviour at one or more of the body's acetylcholine receptor types ("direct-acting").

Cholinergic drug

Main article: Parasympathomimetic drug

A cholinergic drug, also known as a cholinergic agent or a parasympathomimetic drug, is any drug that functions to enhance the effects mediated by acetylcholine in the central nervous system, the peripheral nervous system, or both. These include acetylcholine's precursors and cofactors, acetylcholine receptor agonists and cholinergic enzymes:

• acetylcholine receptor agonists
  • muscarine (muscarinic receptors)
  • pilocarpine (M3 receptors)
  • nicotine (nicotinic receptors)
  • suxamethonium (muscle type receptors)
• cholinesterase inhibitors
  • physostigmine
  • neostigmine

See also

• Dopaminergic
• GABAergic
• Nootropic
• Serotonergic

v • d • e Receptor agonists, antagonists, and reuptake inhibitors
BA/M: 5-HT (serotonin) receptor	Serotonin receptor agonist • Serotonin antagonist (5-HT3) • Serotonin uptake inhibitor (SSRI)
BA/M: Dopamine receptor	Dopamine agonist • Dopamine antagonist • Dopamine reuptake inhibitor
BA/M: Adrenergic receptor	Adrenergic agonist (Alpha, Beta2) • Adrenergic antagonist (Alpha, Beta) • Adrenergic uptake inhibitor
BA/M: Histamine receptor	Histamine agonist • Histamine antagonist (H1, H2)
Acetylcholine receptor	Cholinergic (Muscarinic, Nicotinic) • Anticholinergic (Muscarinic, Nicotinic) • Acetylcholinesterase inhibitor
AA: GABA receptor	GABA agonist • GABA antagonist
AA: Glutamate receptor	NMDA receptor (NMDA receptor antagonist)

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .