Chromosome 17 (human)

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Chromosome 17 is one of the 24 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 17 spans more than 81 million base pairs (the building material of DNA) and represents between 2.5 and 3 % of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 17 likely contains between 1,200 and 1,500 genes. It also contains the Homeobox B gene cluster.

Genes

The following are some of the genes located on chromosome 17:

ACADVL: acyl-coenzyme A dehydrogenase, very long chain
ACTG1: actin, gamma 1
ASPA: aspartoacylase (Canavan disease)
BRCA1: breast cancer 1, early onset
CBX1: chromobox homolog 1
COL1A1: collagen, type I, alpha 1
ERBB2: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
FLCN: folliculin
GALK1: galactokinase 1
GFAP: glial fibrillary acidic protein
KCNJ2: potassium inwardly-rectifying channel, subfamily J, member 2
MYO15A: myosin XVA
NF1: neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease)
PMP22: peripheral myelin protein 22
SHBG: Sex hormone binding globulin
TP53: tumor protein p53 (Li-Fraumeni syndrome)
USH1G: Usher syndrome 1G (autosomal recessive)
RAI1: retinoic acid induced 1
RARalpha: Retenoic Acid Receptor Alpha (involved in t(15,17) with PML)
GRB7: Growth factor Receptor-Bound protein 7
Several CC chemokines: CCL1, CCL2, CCL3, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL14, CCL15, CCL16, CCL18, and CCL23.