Chromosome 20 (human)

You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.

Chromosome 20 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 20 spans around 63 million base pairs (the building material of DNA) and represents between 2 and 2.5 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 20 contains over 900 genes.

Genes

The following are some of the genes located on chromosome 20:

EDN3: endothelin 3
JAG1: jagged 1 (Alagille syndrome)
PANK2: pantothenate kinase 2 (Hallervorden-Spatz syndrome)
PRNP: prion protein (p27-30) (Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)
tTG:tissue transglutaminase (Celiac disease)

Diseases & disorders

The following diseases are some of those related to genes on chromosome 20:

References

Deloukas, P. et al (2001). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865-71. PMID 11780052.
Gilbert, F. (1997). "Disease genes and chromosomes: disease maps of the human genome". Genet Test 1 (3): 225-9. PMID 10464650.