Chromosome 8 (human)

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Chromosome 8 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 8 spans about 155 million base pairs (the building material of DNA) and represents between 4.5 and 5 % of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 8 likely contains between 700 and 1,000 genes.

Genes

The following are some of the genes located on chromosome 8:

FGFR1: fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
GDAP1: ganglioside-induced differentiation-associated protein 1
LPL: lipoprotein lipase
MCPH1: microcephaly, primary autosomal recessive 1
NDRG1: N-myc downstream regulated gene 1
NEF3: neurofilament 3 (150kDa medium)
NEFL: neurofilament, light polypeptide 68kDa
SNAI2: snail homolog 2 (Drosophila)
TG: thyroglobulin
TPA: tissue plasminogen activator
WRN: Werner Syndrome

Diseases & disorders

The following diseases are some of those related to genes on chromosome 8:

References

Gilbert F (2001). "Chromosome 8". Genet Test 5 (4): 345-54. PMID 11960583.
Nusbaum C et al. (2006). "DNA sequence and analysis of human chromosome 8". Nature 439 (7074): 331-5. PMID 16421571.