Chylomicron

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WikiDoc Resources for Chylomicron
Articles
Most recent articles on Chylomicron Most cited articles on Chylomicron Review articles on Chylomicron Articles on Chylomicron in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Chylomicron Images of Chylomicron Photos of Chylomicron Podcasts & MP3s on Chylomicron Videos on Chylomicron
Evidence Based Medicine
Cochrane Collaboration on Chylomicron Bandolier on Chylomicron TRIP on Chylomicron
Clinical Trials
Ongoing Trials on Chylomicron at Clinical Trials.gov Trial results on Chylomicron Clinical Trials on Chylomicron at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Chylomicron NICE Guidance on Chylomicron NHS PRODIGY Guidance FDA on Chylomicron CDC on Chylomicron
Books
Books on Chylomicron
News
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Commentary
Blogs on Chylomicron
Definitions
Definitions of Chylomicron
Patient Resources / Community
Patient resources on Chylomicron Discussion groups on Chylomicron Patient Handouts on Chylomicron Directions to Hospitals Treating Chylomicron Risk calculators and risk factors for Chylomicron
Healthcare Provider Resources
Symptoms of Chylomicron Causes & Risk Factors for Chylomicron Diagnostic studies for Chylomicron Treatment of Chylomicron
Continuing Medical Education (CME)
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International
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List of terms related to Chylomicron

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Chylomicrons are large lipoprotein particles (having a diameter of 75 to 1,200nm) that are created by the absorptive cells of the small intestine.The chylomicrons are released by exocytosis from enterocytes into lacteals, lymphatic vessels originating in the villi of the small intestine, and are then secreted into the bloodstream at the thoracic duct's connection with the left subclavian vein. Chylomicrons transport exogenous lipids to liver, adipose, cardiac and skeletal muscle tissue where they are broken down by lipoprotein lipase into very low density lipoproteins (VLDLs).

Contents when released

Nascent chylomicrons are primarily composed of triglycerides (85%) and contain some cholesterol and cholesteryl esters. The main apolipoprotein component is apolipoprotein B-48 (APOB48).

Changes during circulation

While circulating in lymph and blood, chylomicron exchanges components with High Density Lipoproteins (HDL). The HDL donates apolipoprotein C-II (APOC2) and apolipoprotein E (APOE) to the nascent chylomicron and thus matures it into a "chylomicron." APOC2 is the cofactor for lipoprotein lipase (LPL) activity. Once triglyceride stores are distributed, the chylomicron returns APOC2 (but keeps APOE) back to the HDL and thus becomes a chylomicron remnant. APOB48 and APOE are important to identify the chylomicron remnant in the liver for endocytosis and breakdown.

v • d • e Lipids: lipoprotein metabolism
General	Chylomicron - HDL - LDL - IDL - VLDL - Lp(a)
Apolipoproteins	APOA (1, 2, 5) - APOB - APOC (1, 2, 3, 4) - APOD - APOE - APOH
Other	Lipoprotein lipase - HDL (Cholesterylester transfer proteinAcetyl-CoA C-acyltransferase, LCAT) - LDL receptor - Microsomal triglyceride transfer protein - ABCA1 - Lecithin-cholesterol acyltransferase
see also disorders

v • d • e WikiDoc Research Resources for Chylomicron
Articles on Chylomicron	Most recent articles on Chylomicron • Most cited articles on Chylomicron • Review articles on Chylomicron • Articles on Chylomicron in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Chylomicron	Powerpoint slides on Chylomicron • Images of Chylomicron • Photos of Chylomicron • Podcasts & MP3s on Chylomicron • Videos on Chylomicron
Evidence Based Medicine Regarding Chylomicron	Cochrane Collaboration on Chylomicron • Bandolier on Chylomicron • TRIP on Chylomicron
Cost Effectiveness of Chylomicron	Cost Effectiveness of Chylomicron
Clinical Trials Involving Chylomicron	Ongoing Trials on Chylomicron at Clinical Trials.gov • Trial results on Chylomicron • Clinical Trials on Chylomicron at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Chylomicron	US National Guidelines Clearinghouse on Chylomicron • NICE Guidance on Chylomicron • NHS PRODIGY Guidance • FDA on Chylomicron • CDC on Chylomicron
Textbook Information on Chylomicron	Books and Textbook Information on Chylomicron
Pharmacology Resources on Chylomicron	Dosing of Chylomicron • Drug interactions with Chylomicron • Side effects of Chylomicron • Allergic reactions to Chylomicron • Overdose information on Chylomicron • Carcinogenicity information on Chylomicron • Chylomicron in pregnancy • Pharmacokinetics of Chylomicron •
Genetics, Pharmacogenomics, and Proteinomics of Chylomicron	Genetics of Chylomicron • Pharmacogenomics of Chylomicron • Proteomics of Chylomicron
Newstories on Chylomicron	Chylomicron in the news • Be alerted to news on Chylomicron • News trends on Chylomicron
Commentary on Chylomicron	Blogs on Chylomicron
Patient Resources on Chylomicron	Patient resources on Chylomicron • Discussion groups on Chylomicron • Patient Handouts on Chylomicron • Directions to Hospitals Treating Chylomicron • Risk calculators and risk factors for Chylomicron
Healthcare Provider Resources on Chylomicron	Symptoms of Chylomicron • Causes & Risk Factors for Chylomicron • Diagnostic studies for Chylomicron • Treatment of Chylomicron
Continuing Medical Education (CME) Programs on Chylomicron	CME Programs on Chylomicron
International Resources on Chylomicron	Chylomicron en Espanol • Chylomicron en Francais
Business Resources on Chylomicron	Chylomicron in the Marketplace • Patents on Chylomicron
Informatics Resources on Chylomicron	List of terms related to Chylomicron

de:Chylomikronfr:Chylomicron

it:Chilomicroni nl:Chylomicronfi:Kylomikroni sv:Kylomikron

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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .