Class C GPCR

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7 transmembrane receptor (metabotropic glutamate family)
Identifiers
Symbol	7tm_3
Pfam	PF00003
InterPro	IPR000337

The class C G-protein-coupled receptors (InterPro IPR000337) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors (InterPro IPR000162) and several additional receptors.^[1]

Contents 1 Subfamilies 1.1 Calcium-sensing receptor-related 1.2 GABAB receptors 1.3 Metabotropic glutamate receptors 1.4 RAIG 1.5 Taste receptors 1.6 Orphan 1.7 Other 2 References

Subfamilies

Calcium-sensing receptor-related

• extracellular calcium-sensing receptor-related InterPro IPR000068
  • Calcium-sensing receptor (CASR)
  • GPRC6A (GPRC6A)

GABA_B receptors

• GABA_B receptor (gamma-aminobutyric acid) InterPro IPR002455
  • GABA_B receptor 1 (GABBR1)
  • GABA_B receptor 2 (GABBR2)
  • GPR156 (GPR156)

Metabotropic glutamate receptors

• Metabotropic glutamate receptors (mGluR) InterPro IPR000162
  • mGluR₁ (GRM1)
  • mGluR₂ (GRM2)
  • mGluR₃ (GRM3)
  • mGluR₄ (GRM4)
  • mGluR₅ (GRM5)
  • mGluR₆ (GRM6)
  • mGluR₇ (GRM7)
  • mGluR₈ (GRM8)

RAIG

• Retinoic acid-inducible orphan G protein-coupled receptors (RAIG)
  • RAIG₁ (GPRC5A)
  • RAIG₂ (GPRC5B)
  • RAIG₃ (GPRC5C)
  • RAIG₄ (GPRC5D)

Taste receptors

• Taste receptor
  • Taste receptor, type 1, member 1 (TAS1R1)
  • Taste receptor, type 1, member 2 (TAS1R2)
  • Taste receptor, type 1, member 3 (TAS1R3)

Orphan

• Class C Orphan receptors
  • GPR158 (GPR158)
  • GPR179 (GPR179)

Other

• Bride of sevenless protein InterPro IPR002956
• Vomeronasal receptor, type 2 InterPro IPR004073

References

Template:Membrane-protein-stub

v • d • e Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - Neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)
Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened