Cohesin
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| Cohesin | |
|---|---|
| Image:Cohesin.png Cohesin. Cohesin, binds sister chromatids together during metaphase (PDB: 1w1w). | |
| Genetic data | |
| Gene code: | [1] ID#: GI:2570096 |
| Protein Structure/Function | |
| Structure: | [2]1W1W |
Cohesin is the protein responsible for binding the sister chromatids during mitosis after S phase. At metaphase, most cohesin is removed, except for some at the centromere. At Anaphase, securin, an inhibitory subunit of separase, is hydrolyzed. Separase hydrolyzes the remaining cohesin.
See also
External links
- Michaelis C, Ciosk R, Nasmyth K (1997). "Cohesins: chromosomal proteins that prevent premature separation of sister chromatids". Cell 91 (1): 35-45. PMID 9335333.
- Guacci V, Koshland D, Strunnikov A (1997). "A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae". Cell 91 (1): 47-57. PMID 9335334.
- Tóth A, Ciosk R, Uhlmann F, Galova M, Schleiffer A, Nasmyth K (1999). "Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication". Genes Dev. 13 (3): 320-33. PMID 9990856.
- Uhlmann F, Lottspeich F, Nasmyth K (1999). "Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1". Nature 400 (6739): 37-42. doi:10.1038/21831. PMID 10403247.
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