Complement component 4
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| complement component 4A (Rodgers blood group)
| |
| Identifiers | |
| Symbol | C4A |
| Entrez | 720 |
| HUGO | 1323 |
| OMIM | 120810 |
| RefSeq | NM_007293 |
| UniProt | P0C0L4 |
| Other data | |
| Locus | Chr. 6 p21.3 |
| complement component 4B (Childo blood group)
| |
| Identifiers | |
| Symbol | C4B |
| Entrez | 721 |
| HUGO | 1324 |
| OMIM | 120820 |
| RefSeq | NM_000592 |
| UniProt | P0C0L5 |
| Other data | |
| Locus | Chr. 6 p21.3 |
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Complement component 4 is a protein involved in the complement system.
It is cleaved into proteins 4a and 4b.
- C4a is an anaphylatoxin.
- C4b forms part of C3-convertase, in conjunction with 2a:
- C4b can bind CR1.
Clinical significance
It is responsible for the Chido Rodgers blood group system.[1]
C4d has been identified as a biomarker for systemic lupus erythematosus.[1]
References
Proteins: complement system (C, L, A) | |
|---|---|
| Activators | CLA: C3-convertase - MAC (C6, C7, C8, C9) - L: Mannan-binding lectin - A: Factor P/Properdin |
| Enzymes | C: C1Q/C1R/C1S - C4 - C2 - CLA: C3 - C5 (C5a) - L: MASP1 - MASP2 - A: Factor B - Factor D |
| Inhibitors | CLA: C1-inhibitor - Decay accelerating factor - Factor I - CL: C4BP - A: Factor H |
| Complement receptors | CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin (C3a, C5a) |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
