Coumatetralyl

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Coumatetralyl
Systematic (IUPAC) name
2-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)- 4H-chromen-4-one
Identifiers
CAS number	5836-29-3
PubChem	22095
Chemical data
Formula	C19H16O3
Molar mass	292.329
Complete data

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Coumatetralyl is an anticoagulant of the warfarin type. Symptoms of overexposure relate to failure of the blood clotting mechanism and include bleeding gums and failure of blood clotting after skin wounds. After one exposure the toxicity of coumatetralyl is relatively low, however if overexposure continues for several days the product becomes more toxic. The product must therefore be constantly present in the bloodstream for more than 1 to 2 days in order to be highly toxic. A single exposure, even though relatively large, may not produce toxic symptoms as the compound is quite rapidly metabolised. Chronic animal studies show no evidence of carcinogenic or teratogenic effects.

Common Applications

Coumatetralyl is commonly used with grains and other cereals in conjunction with a tracking powder to monitor feeding activity in a particular area. Tracking powder also clings to fur, which allows more poison to be ingested from grooming. Concentrations of the chemical are usually 500mg per 1 kg of bait.

Treatment

Vitamin K1 (phylloquinone) is antidotal. If swallowed, and if more than 15 minutes from a hospital, inducing vomiting is recommended, providing the patient is conscious, preferably using a correct emetic. If present on the skin, washing the material off the skin with soap and water is recocomended. If in the eye, holding the eye open and flooding with water for at least 15 minutes is recommended in addition to seeing a doctor.

External links

• Product Example

v • d • e Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)
Vitamin K antagonists	Acenocoumarol • Clorindione • Coumatetralyl • Dicumarol (Dicoumarol) • Diphenadione • Ethyl biscoumacetate • Phenprocoumon • Phenindione • Tioclomarol • Warfarin
Heparin group	Antithrombin III • Danaparoid • Heparin • Sulodexide • low molecular weight heparin (Bemiparin, Dalteparin, Enoxaparin, Nadroparin, Parnaparin, Reviparin, Tinzaparin)
Glycoprotein IIb/IIIa inhibitors	Abciximab • Eptifibatide • Tirofiban
Other platelet aggregation inhibitors	Acetylsalicylic acid/Aspirin • Aloxiprin • Ditazole • Carbasalate calcium • Cloricromen • Dipyridamole • Indobufen • Picotamide • Triflusal • ADP receptor inhibitors (Clopidogrel, Ticlopidine, Prasugrel) • prostaglandin analogue (Beraprost, Prostacyclin, Iloprost, Treprostinil)
Enzymes	plasminogen activators (Alteplase/Reteplase/Tenecteplase, Streptokinase, Urokinase/Saruplase, Anistreplase) • other serine endopeptidases (Ancrod, Drotrecogin alfa/Protein C, Fibrinolysin) • Brinase
Direct thrombin inhibitors	Argatroban • Bivalirudin • Dabigatran • Desirudin • Hirudin • Lepirudin • Melagatran • Ximelagatran
Other antithrombotics	Apixaban • Defibrotide • Dermatan sulfate • Fondaparinux • Idraparinux • Otamixaban • Rivaroxaban
Non-medicinal	Citrate • EDTA • Oxalate

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .