Cutaneous T cell lymphoma

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Cutaneous T cell lymphoma Classification and external resources
ICD-10	C84.0, C84.1
ICD-9	202.1, 202.2
ICD-O:	M9700/3, M9701/3
DiseasesDB	8595
eMedicine	med/3486
MeSH	D016410

WikiDoc Resources for Cutaneous T cell lymphoma
Articles
Most recent articles on Cutaneous T cell lymphoma Most cited articles on Cutaneous T cell lymphoma Review articles on Cutaneous T cell lymphoma Articles on Cutaneous T cell lymphoma in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Cutaneous T cell lymphoma Images of Cutaneous T cell lymphoma Photos of Cutaneous T cell lymphoma Podcasts & MP3s on Cutaneous T cell lymphoma Videos on Cutaneous T cell lymphoma
Evidence Based Medicine
Cochrane Collaboration on Cutaneous T cell lymphoma Bandolier on Cutaneous T cell lymphoma TRIP on Cutaneous T cell lymphoma
Clinical Trials
Ongoing Trials on Cutaneous T cell lymphoma at Clinical Trials.gov Trial results on Cutaneous T cell lymphoma Clinical Trials on Cutaneous T cell lymphoma at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Cutaneous T cell lymphoma NICE Guidance on Cutaneous T cell lymphoma NHS PRODIGY Guidance FDA on Cutaneous T cell lymphoma CDC on Cutaneous T cell lymphoma
Books
Books on Cutaneous T cell lymphoma
News
Cutaneous T cell lymphoma in the news Be alerted to news on Cutaneous T cell lymphoma News trends on Cutaneous T cell lymphoma
Commentary
Blogs on Cutaneous T cell lymphoma
Definitions
Definitions of Cutaneous T cell lymphoma
Patient Resources / Community
Patient resources on Cutaneous T cell lymphoma Discussion groups on Cutaneous T cell lymphoma Patient Handouts on Cutaneous T cell lymphoma Directions to Hospitals Treating Cutaneous T cell lymphoma Risk calculators and risk factors for Cutaneous T cell lymphoma
Healthcare Provider Resources
Symptoms of Cutaneous T cell lymphoma Causes & Risk Factors for Cutaneous T cell lymphoma Diagnostic studies for Cutaneous T cell lymphoma Treatment of Cutaneous T cell lymphoma
Continuing Medical Education (CME)
CME Programs on Cutaneous T cell lymphoma
International
Cutaneous T cell lymphoma en Espanol Cutaneous T cell lymphoma en Francais
Businness
Cutaneous T cell lymphoma in the Marketplace Patents on Cutaneous T cell lymphoma
Experimental / Informatics
List of terms related to Cutaneous T cell lymphoma

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Overview

Cutaneous T-Cell lymphoma (CTCL) is a class of non-Hodgkin's lymphoma, which is a type of cancer of the immune system. Unlike most non-Hodgkin's lymphomas (which are generally B-cell related), CTCL is caused by a mutation of T cells. The malignant T cells in the body are pushed to the surface of the skin in a biological process used to rid the body of offending material, causing various lesions to appear on the skin. These lesions change shape as the disease progresses, typically beginning as what appears to be a rash and eventually forming plaques and tumors before metastatizing to other parts of the body.

Types

Though there are many types of CTCL and presentation can vary from individual to individual, there are two main forms:

• mycosis fungoides (MF)
• Sézary syndrome (SS)

There is some dispute over whether SS is an advanced form of MF or a different type of CTCL entirely - in either case, the prognosis for SS patients is substantially poorer than for those of MF.

Treatment

There is no cure for CTCL, but there are a variety of treatment options available and some CTCL patients are able to live somewhat normal lives with this cancer, although symptoms can be debilitating and painful, even in earlier stages.

Treatments include: Topical Corticosteroids, Bexarotene Gel, Carmustine(Nitrogen Mustard), Mechlorethamine, Phototherapy (Broad & Narrow Band UVB or PUVA), Local & Total Skin Electron Beam Radiation, Conventional Radiation Therapy, Oral Corticosteroids, Bexarotene (Targretin®) Capsules, Photopheresis, Interferons, Denileukin Diftitox (Ontak®), Alemtuzumab (Campath-1H), Vorinostat (Zolinza®), Methotrexate, Pentostatin & other purine analogues (Fludarabine, 2- deoxychloroadenosine), Liposomal doxorubicin (Doxil®), Gemcitabine (Gemzar®), Cyclophosphamide, oral, Bone marrow/Stem cell, and Allogenic Transplantation.

See also

• Anaplastic large cell lymphoma

External links

• Cutaneous T-Cell Lymphomas - The lymphoma Information Network
• The Cutaneous Lymphoma Foundation
• DermNet dermal-infiltrative/cutaneous-t-cell-lymphoma

• Lymphoma Research Foundation
• Cutaneous T-cell Lymphoma - H. Lee Moffitt Cancer Center & Research Institute
• UUHSC
• NCI Clinical Trial using Depsipeptide to treat CTCL

v • d • e Pathology: hematology, myeloid hematologic disease (primarily D50-D77, 280-289)
RBCs/ hemoglobinopathy	+ Polycythemia - Macrocytosis - Anemia Nutritional Iron deficiency anemia (Plummer-Vinson syndrome), Megaloblastic anemia (Pernicious anemia) Hemolytic Hereditary enzyme: G6PD Deficiency - Pyruvate kinase deficiency - Triosephosphate isomerase deficiency hemoglobin: Thalassemia - Sickle-cell disease/trait membrane: Hereditary spherocytosis - Hereditary elliptocytosis - Hereditary stomatocytosis Acquired Autoimmune (Warm, Cold), HUS, MAHA, PNH, PCH, Myelophthisic Aplastic Acquired PRCA, Diamond-Blackfan anemia, Fanconi anemia, Sideroblastic anemia Blood tests Normocytic - Microcytic - Macrocytic - Normochromic - Hypochromic Other Methemoglobinemia
Coagulation/platelets/ coagulopathy/ bleeding diathesis	+ Hypercoagulability primary: Antithrombin III deficiency - Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden - Hyperprothrombinemia acquired: DIC (Congenital afibrinogenemia, Purpura fulminans) - autoimmune (Antiphospholipid) Other Essential thrombocytosis - clotting factor: Hemophilia (A/VIII, B/IX, C/XI) • Von Willebrand disease • Hypoprothrombinemia/II - XIII platelet function: Bernard-Soulier syndrome - Glanzmann's thrombasthenia - Gray platelet syndrome - May Hegglin anomaly - Pelger-Huet anomaly Purpura: Henoch-Schönlein, ITP (Evans syndrome), TTP Thrombocytopenia (Heparin-induced thrombocytopenia)
Monocytes/ macrophages	+ Histiocytosis WHO-I (Langerhans cell histiocytosis) WHO-II/non-Langerhans-cell (Juvenile xanthogranuloma, Hemophagocytic lymphohistiocytosis) WHO-III/malignant (Acute monocytic leukemia, Malignant histiocytosis, Erdheim-Chester disease) Other Chronic granulomatous disease -cytosis: Monocytosis - -penia: Monocytopenia
Granulocytes	+ -cytosis: granulocytosis (Neutrophilia, Eosinophilia, Basophilia) - -penia: Granulocytopenia/agranulocytosis (Neutropenia, Kostmann syndrome)
See also hematological malignancy and immune disorders

v • d • e WikiDoc Research Resources for Cutaneous T cell lymphoma
Articles on Cutaneous T cell lymphoma	Most recent articles on Cutaneous T cell lymphoma • Most cited articles on Cutaneous T cell lymphoma • Review articles on Cutaneous T cell lymphoma • Articles on Cutaneous T cell lymphoma in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Cutaneous T cell lymphoma	Powerpoint slides on Cutaneous T cell lymphoma • Images of Cutaneous T cell lymphoma • Photos of Cutaneous T cell lymphoma • Podcasts & MP3s on Cutaneous T cell lymphoma • Videos on Cutaneous T cell lymphoma
Evidence Based Medicine Regarding Cutaneous T cell lymphoma	Cochrane Collaboration on Cutaneous T cell lymphoma • Bandolier on Cutaneous T cell lymphoma • TRIP on Cutaneous T cell lymphoma
Cost Effectiveness of Cutaneous T cell lymphoma	Cost Effectiveness of Cutaneous T cell lymphoma
Clinical Trials Involving Cutaneous T cell lymphoma	Ongoing Trials on Cutaneous T cell lymphoma at Clinical Trials.gov • Trial results on Cutaneous T cell lymphoma • Clinical Trials on Cutaneous T cell lymphoma at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Cutaneous T cell lymphoma	US National Guidelines Clearinghouse on Cutaneous T cell lymphoma • NICE Guidance on Cutaneous T cell lymphoma • NHS PRODIGY Guidance • FDA on Cutaneous T cell lymphoma • CDC on Cutaneous T cell lymphoma
Textbook Information on Cutaneous T cell lymphoma	Books and Textbook Information on Cutaneous T cell lymphoma
Pharmacology Resources on Cutaneous T cell lymphoma	Dosing of Cutaneous T cell lymphoma • Drug interactions with Cutaneous T cell lymphoma • Side effects of Cutaneous T cell lymphoma • Allergic reactions to Cutaneous T cell lymphoma • Overdose information on Cutaneous T cell lymphoma • Carcinogenicity information on Cutaneous T cell lymphoma • Cutaneous T cell lymphoma in pregnancy • Pharmacokinetics of Cutaneous T cell lymphoma •
Genetics, Pharmacogenomics, and Proteinomics of Cutaneous T cell lymphoma	Genetics of Cutaneous T cell lymphoma • Pharmacogenomics of Cutaneous T cell lymphoma • Proteomics of Cutaneous T cell lymphoma
Newstories on Cutaneous T cell lymphoma	Cutaneous T cell lymphoma in the news • Be alerted to news on Cutaneous T cell lymphoma • News trends on Cutaneous T cell lymphoma
Commentary on Cutaneous T cell lymphoma	Blogs on Cutaneous T cell lymphoma
Patient Resources on Cutaneous T cell lymphoma	Patient resources on Cutaneous T cell lymphoma • Discussion groups on Cutaneous T cell lymphoma • Patient Handouts on Cutaneous T cell lymphoma • Directions to Hospitals Treating Cutaneous T cell lymphoma • Risk calculators and risk factors for Cutaneous T cell lymphoma
Healthcare Provider Resources on Cutaneous T cell lymphoma	Symptoms of Cutaneous T cell lymphoma • Causes & Risk Factors for Cutaneous T cell lymphoma • Diagnostic studies for Cutaneous T cell lymphoma • Treatment of Cutaneous T cell lymphoma
Continuing Medical Education (CME) Programs on Cutaneous T cell lymphoma	CME Programs on Cutaneous T cell lymphoma
International Resources on Cutaneous T cell lymphoma	Cutaneous T cell lymphoma en Espanol • Cutaneous T cell lymphoma en Francais
Business Resources on Cutaneous T cell lymphoma	Cutaneous T cell lymphoma in the Marketplace • Patents on Cutaneous T cell lymphoma
Informatics Resources on Cutaneous T cell lymphoma	List of terms related to Cutaneous T cell lymphoma

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .