Cystathionine-beta-lyase
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In enzymology, a cystathionine beta-lyase (EC 4.4.1.8) is an enzyme that catalyzes the chemical reaction
- L-cystathionine + H2O
L-homocysteine + NH3 + pyruvate
Thus, the two substrates of this enzyme are L-cystathionine and H2O, whereas its 3 products are L-homocysteine, NH3, and pyruvate.
This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming). Other names in common use include beta-cystathionase, cystine lyase, cystathionine L-homocysteine-lyase (deaminating), and L-cystathionine L-homocysteine-lyase (deaminating). This enzyme participates in 5 metabolic pathways: methionine metabolism, cysteine metabolism, selenoamino acid metabolism, nitrogen metabolism, and sulfur metabolism. It employs one cofactor, pyridoxal phosphate.
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Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1CL1, 1CL2, 1IBJ, 2FQ6, and 2GQN.
References
- IUBMB entry for 4.4.1.8
- BRENDA references for 4.4.1.8 (Recommended.)
- PubMed references for 4.4.1.8
- PubMed Central references for 4.4.1.8
- Google Scholar references for 4.4.1.8
- Anderson NW and Thompson JF (1979). "Cystine lyase: beta-cystathionase from turnip roots". Phytochemistry 18: 1953–1958.
- FLAVIN M, SLAUGHTER C (1964). "CYSTATHIONINE CLEAVAGE ENZYMES OF NEUROSPORA". J. Biol. Chem. 239: 2212–9. PMID 14209950.
External links
- The CAS registry number for this enzyme class is 9055-05-4.
