De Quervain's thyroiditis
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| De Quervain's thyroiditis Classification and external resources | |
| ICD-10 | E06.1 |
|---|---|
| ICD-9 | 245.1 |
| DiseasesDB | 3474 |
| eMedicine | med/534 |
| MeSH | D013968 |
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de Quervain's thyroiditis, is also known as subacute granulomatous thyroiditis or subacute thyroiditis; usually occurs in women between 30 and 50 years of age. It is a member of the group of thyroiditis conditions known as resolving thyroiditis.
Causes
Some cases may be viral in origin, perhaps preceded by an upper respiratory tract infection. Some cases develop postpartum.
Presentation
Patients will experience a hyperthyroid period as the cellular lining of colloid spaces fails, allowing abundant colloid into the circulation, with neck pain and fever. Patients typically then become hypothyroid as the pituitary reduces TSH production and the inappropriately released colloid is depleted before resolving to euthyroid. The symptoms are those of hyperthyroidism and hypothyroidism. In addition, patients may suffer from painful dysphagia. There are multi-nucleated giant cells on histology.
Treatment
Treatment is NSAID.
Corticosteroids may be of help in refractory cases.
Eponym
It is named for Fritz de Quervain.[1] It should not be confused with DeQuervain's syndrome.
References
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
