De humani corporis fabrica
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De humani corporis fabrica libri septem (On the fabric of the human body in seven books) is a textbook of human anatomy written by Andreas Vesalius (1514-1564) in 1543.
The book is based on his Paduan lectures, during which he deviated from common practice by dissecting a corpse to illustrate what he was discussing. It presents a careful examination of the organs and the complete structure of the human body. This would not have been possible without the many advances that had been made during the Renaissance, including both the artistic developments and the technical development of printing. Because of this, he was able to produce illustrations superior to any that had been produced up to then.
Fabrica rectified some of Galen's worst errors, including the notion that the great blood vessels originated from the liver. Even with his improvements, however, Vesalius clung to some of Galen's errors, such as the idea that there was a different type of blood flowing through each the veins and arteries. It was not until William Harvey's work on the circulation of the blood that this misconception of Galen would be rectified.
Vesalius had the work published at the age of 28, taking great pains to ensure its quality. Many of the illustrations were made by commissioned artists—those in the first two books were done by Johannes Stephanus of Calcar, an employee/student of the great Venetian artist Titian—and were greatly superior to the illustrations in anatomical atlases of the day, which were often made by anatomy professors themselves. The woodcuts were transported to Basel, Switzerland, as Vesalius wished that the work be published by one of the foremost printers of the time, Joannis Oporini.
The success of Fabrica ensured the health of Vesalius' coffers, and in time, fame. He was appointed physician to the Holy Roman Emperor Charles V; Vesalius had dedicated the work to the ruler, and presented him with the first published copy (bound in silk of imperial purple, with specially hand-painted illustrations not found in any other copy). The Fabrica was republished in 1555.
A copy of the book clad in human skin was donated to Brown University's John Hay Library by an alumnus. Its cover is "polished to a smooth golden brown" and, according to those who have seen the book, it looks like fine leather. Covering books in human skin was not an uncommon practice a couple of centuries ago, utilizing the skin of executed convicts and poor people who died with no one to claim the body.[1]
Of pharmacological interest, Fabrica mentions Digitalis, which is still an important Inotropic Agent used to treat congestive heart failure.
References
- O'Malley, CD. Andreas Vesalius of Brussels, 1514-1564. Berkeley: University of California Press, 1964.
- Richardson, WF (trans). On the Fabric of the Human Body: A Translation of De corporis humani fabrica. San Francisco: Norman Publishing, 1998- (ongoing).
- Vesalius, A. De humanis corporis fabrica libri septem [Title page: Andreae Vesalii Bruxellensis, scholae medicorum Patauinae professoris De humani corporis fabrica libri septem]. Basileae [Basel]: Ex officina Joannis Oporini, 1543.
External links
- Turning the Pages Online. A U.S. National Library of Medicine project to digitize images and plates from "rare and beautiful historic books in the biomedical sciences".
- De Humani Corporis Fabrica online — translated with full images, from Northwestern Universityfr:De humani corporis fabricasv:De humani corporis fabrica libri septem
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
