Death associated protein 6

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Death-associated protein 6
Identifiers
Symbol(s) DAXX; BING2; DAP6; MGC126245; MGC126246
External IDs OMIM: 603186 MGI: 1197015 Homologene: 1033
RNA expression pattern

Image:PBB GE DAXX 201763 s at tn.png

Image:PBB GE DAXX 216038 x at tn.png

More reference expression data

Orthologs
Human Mouse
Entrez 1616 13163
Ensembl ENSG00000204209 ENSMUSG00000002307
Uniprot Q9UER7 A1A558
Refseq NM_001350 (mRNA)
NP_001341 (protein) 		XM_993766 (mRNA)
XP_998860 (protein)
Location Chr 6: 33.39 - 33.4 Mb Chr 17: 33.52 - 33.53 Mb
Pubmed search [1] [2]

Death-associated protein 6, also known as DAXX, is a human gene. TGF beta may trigger apoptosis via the DAXX adapter protein. DAXX has been shown to associate with and bind to the type II TGF beta receptor kinase.



Pathway

The DAXX Pathway
The DAXX Pathway

See also

External links

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
  • Yang X, Khosravi-Far R, Chang HY, Baltimore D (1997). "Daxx, a novel Fas-binding protein that activates JNK and apoptosis.". Cell 89 (7): 1067-76. PMID 9215629.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
  • Kiriakidou M, Driscoll DA, Lopez-Guisa JM, Strauss JF (1998). "Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region.". DNA Cell Biol. 16 (11): 1289-98. PMID 9407001.
  • Herberg JA, Sgouros J, Jones T, et al. (1998). "Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC.". Eur. J. Immunol. 28 (2): 459-67. PMID 9521053.
  • Herberg JA, Beck S, Trowsdale J (1998). "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC.". J. Mol. Biol. 277 (4): 839-57. doi:10.1006/jmbi.1998.1637. PMID 9545376.
  • Pluta AF, Earnshaw WC, Goldberg IG (1998). "Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death.". J. Cell. Sci. 111 ( Pt 14): 2029-41. PMID 9645950.
  • Chang HY, Nishitoh H, Yang X, et al. (1998). "Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx.". Science 281 (5384): 1860-3. PMID 9743501.
  • Hollenbach AD, Sublett JE, McPherson CJ, Grosveld G (1999). "The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx.". EMBO J. 18 (13): 3702-11. doi:10.1093/emboj/18.13.3702. PMID 10393185.
  • Michaelson JS, Bader D, Kuo F, et al. (1999). "Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development.". Genes Dev. 13 (15): 1918-23. PMID 10444590.
  • Ishov AM, Sotnikov AG, Negorev D, et al. (1999). "PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1.". J. Cell Biol. 147 (2): 221-34. PMID 10525530.
  • Li H, Leo C, Zhu J, et al. (2000). "Sequestration and inhibition of Daxx-mediated transcriptional repression by PML.". Mol. Cell. Biol. 20 (5): 1784-96. PMID 10669754.
  • Zhong S, Salomoni P, Ronchetti S, et al. (2000). "Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis.". J. Exp. Med. 191 (4): 631-40. PMID 10684855.
  • Li R, Pei H, Watson DK, Papas TS (2000). "EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes.". Oncogene 19 (6): 745-53. doi:10.1038/sj.onc.1203385. PMID 10698492.
  • Charette SJ, Lavoie JN, Lambert H, Landry J (2000). "Inhibition of Daxx-mediated apoptosis by heat shock protein 27.". Mol. Cell. Biol. 20 (20): 7602-12. PMID 11003656.
  • Rochat-Steiner V, Becker K, Micheau O, et al. (2000). "FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation.". J. Exp. Med. 192 (8): 1165-74. PMID 11034606.
  • Ryu SW, Chae SK, Kim E (2001). "Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9.". Biochem. Biophys. Res. Commun. 279 (1): 6-10. doi:10.1006/bbrc.2000.3882. PMID 11112409.
  • Charette SJ, Landry J (2001). "The interaction of HSP27 with Daxx identifies a potential regulatory role of HSP27 in Fas-induced apoptosis.". Ann. N. Y. Acad. Sci. 926: 126-31. PMID 11193028.
  • Lehembre F, Müller S, Pandolfi PP, Dejean A (2001). "Regulation of Pax3 transcriptional activity by SUMO-1-modified PML.". Oncogene 20 (1): 1-9. doi:10.1038/sj.onc.1204063. PMID 11244500.
  • Perlman R, Schiemann WP, Brooks MW, et al. (2001). "TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation.". Nat. Cell Biol. 3 (8): 708-14. doi:10.1038/35087019. PMID 11483955.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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