Decay accelerating factor

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CD55 molecule, decay accelerating factor for complement (Cromer blood group)
Identifiers
Symbol	CD55
Alt. Symbols	DAF
Entrez	1604
HUGO	2665
OMIM	125240
RefSeq	NM_000574
UniProt	P08174
Other data
Locus	Chr. 1 q32

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Decay accelerating factor (CD55) is a 70 kDa membrane protein that regulates the complement system on the cell surface. It prevents the assembly of the C3bBb complex (the C3-convertase of the alternative pathway) or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.

This glycoprotein is broadly distributed among hematopoietic and non-hematopoietic cells. It is a determinant for the Cromer blood group system.

Pathology

DAF is not expressed on paroxysmal nocturnal hemoglobinuria III (markedly abnormal) RBCs; however, this deficiency is not the cause of PNH.

See also

• List of human clusters of differentiation

External links

• MeSH Decay-Accelerating+Factor
• Cromer blood group system at BGMUT, Blood Group Antigen Gene Mutation Database at NCBI, NIH

v • d • e Proteins: complement system (C, L, A)
Activators	CLA: C3-convertase - MAC (C6, C7, C8, C9) - L: Mannan-binding lectin - A: Factor P/Properdin
Enzymes	C: C1Q/C1R/C1S - C4 - C2 - CLA: C3 - C5 (C5a) - L: MASP1 - MASP2 - A: Factor B - Factor D
Inhibitors	CLA: C1-inhibitor - Decay accelerating factor - Factor I - CL: C4BP - A: Factor H
Complement receptors	CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin (C3a, C5a)

v • d • e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50	CD1 (CD1a-c, CD1d) - CD2 - CD3 - CD4 - CD5 - CD8 - CD9 - CD10 - CD11 (CD11a, CD11b, CD11c) - CD13 - CD14 - CD15 - CD16 - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 - CD33 - CD34 - CD35 - CD36 - CD37 -CD38 - CD40 - CD43 - CD44 - CD45 - CD46 - CD49 (CD49a, CD49b, CD49c, CD49d)
51-100	CD52 - CD53 - CD54 - CD55 - CD56 - CD58 - CD59 - CD61 - CD62 (CD62E, CD62L, CD62P) - CD63 - CD64 - CD66e - CD68 - CD70 - CD71 - CD72 - CD79 - CD80 - CD81 - CD82 - CD83 - CD86 - CD88 - CD89 - CD90 - CD94 - CD95 - CD97 - CD98
101-350	CD103 - CD106 - CD114 - CD116 - CD117 - CD118 - CD120 - CD122 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD137 - CD138 - CD141 - CD142 - CD143 - CD146 - CD147 - CD151 - CD152 - CD153 - CD154 - CD155 - CD162 - CD164 - CD169 - CD184 - CD206 - CD209 - CD257 - CD278 - CD281 - CD282 - CD283 - CD304

v • d • e WikiDoc Research Resources for Decay accelerating factor (Click show to right to view)
Articles on Decay accelerating factor	Most recent articles on Decay accelerating factor • Most cited articles on Decay accelerating factor • Review articles on Decay accelerating factor • Articles on Decay accelerating factor in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Decay accelerating factor	Powerpoint slides on Decay accelerating factor • Images of Decay accelerating factor • Photos of Decay accelerating factor • Podcasts & MP3s on Decay accelerating factor • Videos on Decay accelerating factor
Evidence Based Medicine Regarding Decay accelerating factor	Cochrane Collaboration on Decay accelerating factor • Bandolier on Decay accelerating factor • TRIP on Decay accelerating factor
Cost Effectiveness of Decay accelerating factor	Cost Effectiveness of Decay accelerating factor
Clinical Trials Involving Decay accelerating factor	Ongoing Trials on Decay accelerating factor at Clinical Trials.gov • Trial results on Decay accelerating factor • Clinical Trials on Decay accelerating factor at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Decay accelerating factor	US National Guidelines Clearinghouse on Decay accelerating factor • NICE Guidance on Decay accelerating factor • NHS PRODIGY Guidance • FDA on Decay accelerating factor • CDC on Decay accelerating factor
Textbook Information on Decay accelerating factor	Books and Textbook Information on Decay accelerating factor
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Genetics, Pharmacogenomics, and Proteinomics of Decay accelerating factor	Genetics of Decay accelerating factor • Pharmacogenomics of Decay accelerating factor • Proteomics of Decay accelerating factor
Newstories on Decay accelerating factor	Decay accelerating factor in the news • Be alerted to news on Decay accelerating factor • News trends on Decay accelerating factor
Commentary on Decay accelerating factor	Blogs on Decay accelerating factor
Patient Resources on Decay accelerating factor	Patient resources on Decay accelerating factor • Discussion groups on Decay accelerating factor • Patient Handouts on Decay accelerating factor • Directions to Hospitals Treating Decay accelerating factor • Risk calculators and risk factors for Decay accelerating factor
Healthcare Provider Resources on Decay accelerating factor	Symptoms of Decay accelerating factor • Causes & Risk Factors for Decay accelerating factor • Diagnostic studies for Decay accelerating factor • Treatment of Decay accelerating factor
Continuing Medical Education (CME) Programs on Decay accelerating factor	CME Programs on Decay accelerating factor
International Resources on Decay accelerating factor	Decay accelerating factor en Espanol • Decay accelerating factor en Francais
Business Resources on Decay accelerating factor	Decay accelerating factor in the Marketplace • Patents on Decay accelerating factor
Informatics Resources on Decay accelerating factor	List of terms related to Decay accelerating factor

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .