Depressant

You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.

(Redirected from Depressants)
Jump to: navigation, search

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

A depressant, referred to in slang as a "downer," is a chemical agent that diminishes the function or activity of a specific part of the body. (See also sedative.) The term is used in particular with regard to the central nervous system (CNS). Alcohol (consumed in alcoholic beverages) is the most obvious example of a depressant. Many depressants acting on the CNS do so by increasing the activity of a particular neurotransmitter known as gamma-aminobutyric acid (GABA), although other targets such as the NMDA receptor, mu-opioid receptor and CB1 cannabinoid receptor can also be important, depending on which drug is involved.

GABA's task is to calm the CNS and to promote sleep. Drugs that stimulate the activity of this amino acid produce slowed brain function and a drowsy or calm feeling, and so depressants are generally prescribed to relieve symptoms of anxiety or insomnia. Internal systems regulate the body's production of GABA, but when medication is taken to stimulate GABA action, it is possible to induce hazardously high levels, which can dangerously slow breathing and heart rates, and may result in death.

CNS depressants require a period of adaptation. Typically, initial side effects include slurred speech, dizziness, and loss of coordination, in many respects similar to the effects of alcohol.

The most common medically used depressants generally fall into two classes, namely barbiturates and benzodiazepines. Other depressants include alcohol, narcotics (opiate derivatives), sedative-hypnotics, first-generation antihistamines (such as diphenhydramine,) and some anaesthetics (such as ketamine and phencyclidine).

Barbiturates are effective in relieving the conditions they are designed to address; they are also readily abused, physically addictive, and have serious potential for overdose. When, in the late 1960s, it became clear that the social cost of barbiturates was beginning to outweigh the medical benefits, a serious search began for a replacement drug. (See Methaqualone) Most people still using barbiturates today do so in the prevention of seizures or in mild form for relief from the symptoms of migraines.

Benzodiazepines mediate many of the same symptoms as barbiturates, but are far less toxic and have a strongly reduced risk of overdose. This is not to say they are not without their own risks; where barbiturates pose a greater "front-end" danger in that overdose or drug/alcohol interactions may result in fatality, benzodiazepines pose a greater "back-end" risk in the possibility of addiction, dependence, and serious physical and psychological withdrawal symptoms. Immediate cessation of long-term benzodiazepine use instead of tapering can be dangerous and have serious effects.

Combining multiple depressants is generally recognized as very dangerous due to the fact that the CNS depressive properties often increase multiplicatively instead of linearly. This characteristic makes depressants a common choice for deliberate overdoses in the case of suicide. The use of alcohol or benzodizepines along with the usual dose of heroin is often the reason of the overdose death of opiates addicted.


Depressants/Downers

External links


WikiDoc Help Menu

Quick Start..

Editing basics

Advanced editing

Communicating your edits

Help Videos You Can Watch


Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

et:Närvisüsteemi depressant fr:Dépresseur gl:Depresoras(drogas) sr:Даунери fi:Depressantti

Retrieved from "http://en.wikidoc.org/index.php/Depressant"
Personal tools