Digoxin Immune Fab
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| Digoxin Immune Fab
| |
| Systematic (IUPAC) name | |
| Anti-digoxin antibody fragment | |
| Identifiers | |
| CAS number | ? |
| ATC code | V03 |
| PubChem | ? |
| DrugBank | |
| Chemical data | |
| Formula | C6394H9908N1698O2011S58 |
| Mol. mass | 144602.257 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | 15 hours for DigiFab, 23 hours for Digibind |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
C(US) |
| Legal status | |
| Routes | IV infusion, injection |
Digoxin Immune Fab (Ovine) is the generic name for an antidote for overdose of digitalis.[1] It is made from immunoglobin fragments from sheep who have already been immunized with a digoxin derivative, digoxindicarboxymethoxylamine (DDMA). Its brand names include Digibind and DigiFab, with the former manufactured by GlaxoSmithKline and the latter manufactured by Protherics, Inc.
Contents |
Pharmacology
It works by binding to the digoxin, rendering them unable to bind to their action sites on target cells. The complexes accumulate in the blood and are expelled by the kidney.
Contraindications
Although no contraindications have been noted, the patient must be closely monitored for anaphylactic shock, and anyone allergic to sheep protein, papain, bromelain, or papaya extracts (papain is used to cleave the antibody into Fab and Fc fragments) should not use Digoxin Immune Fab (Ovine). Because it is relatively new, no drug interaction studies have been performed yet.
References
- ↑ DiDomenico RJ, Walton SM, Sanoski CA, Bauman JL (2000). "Analysis of the use of digoxin immune fab for the treatment of non-life-threatening digoxin toxicity". J. Cardiovasc. Pharmacol. Ther. 5 (2): 77–85. PMID 11150387.
External links
Antidotes (V03AB) | |
|---|---|
| Methanol / Ethylene glycol | Ethanol - Fomepizole |
| Paracetamol (Acetaminophen) | Acetylcysteine - Glutathione - Methionine |
| Arsenic | Dimercaprol - Succimer |
| Cyanide | 4-Dimethylaminophenol - Amyl nitrite - Hydroxocobalamin - Sodium nitrite - Sodium thiosulfate |
| Heparin | Protamine |
| Nerve agent / Organophosphate pesticide | Atropine - Biperiden - Diazepam - Oximes (Pralidoxime, Obidoxime) - see also Cholinesterase |
| Opioid | Diprenorphine - Nalorphine - Naloxone - Naltrexone - Nalmefene |
| Benzodiazepine | Flumazenil |
| Toxic metals (Cadmium, Mercury, Lead etc) | Edetates - Dimercaprol |
| Other | Ipecacuanha - Prednisolone/promethazine - Methylthioninium chloride - Potassium permanganate - Physostigmine - Copper sulfate - Potassium iodide - Digoxin Immune Fab - Prussian blue |
