Dihydroorotate dehydrogenase
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| dihydroorotate dehydrogenase
| |
| Identifiers | |
| Symbol | DHODH |
| Entrez | 1723 |
| HUGO | 2867 |
| OMIM | 126064 |
| RefSeq | NM_001361 |
| UniProt | Q02127 |
| Other data | |
| EC number | 1.3.3.1 |
| Locus | Chr. 16 q22 |
Dihydroorotate dehydrogenase is an enzyme involved in pyrimidine biosynthesis.
It converts dihydroorotate to orotate:
4,5-Dihydroorotic acid.svg
|
 Orotic acid. Note the double bond in the ring. |
External links
Oxidoreductases: CH-CH oxidoreductases (EC 1.3) | |
|---|---|
| 1.3.1. NAD/NADP acceptor | Enoyl-acyl carrier protein reductase/Enoyl ACP reductase - 7-Dehydrocholesterol reductase - Biliverdin reductase - 2,4 Dienoyl-CoA reductase |
| 1.3.3. Oxygen acceptor | Dihydroorotate dehydrogenase - Coproporphyrinogen III oxidase - Protoporphyrinogen oxidase - |
| 1.3.5. Quinone | Succinate - coenzyme Q reductase |
| 1.3.99. Other acceptors | Fumarate reductase - Butyryl CoA dehydrogenase - Acyl CoA dehydrogenase - 5-alpha reductase - Glutaryl-CoA dehydrogenase - Isovaleryl coenzyme A dehydrogenase |
Mitochondrial enzymes and transporters | |
|---|---|
| Outer membrane | Long fatty acyl CoA synthetase - Kynureninase - Monoamine oxidase |
| Intermembrane space | Adenylate kinase - Creatine kinase |
| Inner membrane | Coenzyme Q - cytochrome c reductase -Cytochrome c - Dihydroorotate dehydrogenase -Glutamate aspartate transporter - Glycerol-3-phosphate dehydrogenase - NADH dehydrogenase - Succinate dehydrogenase |
| Matrix | Aconitase - Aspartate transaminase - ALDH2 - Carbamoyl phosphate synthase - Citrate synthase - Fumarase - Glutamate dehydrogenase - Isocitrate dehydrogenase - Malate dehydrogenase - Ornithine transcarbamoylase - Oxoglutarate dehydrogenase - Pyruvate dehydrogenase complex - Succinyl coenzyme A synthetase |
| Mitochondrial DNA | Complex I (7 units) - Complex III (1 unit) - Complex IV (3 units) - ATP synthase (2 units) |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
