Dihydropyrimidine dehydrogenase deficiency

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Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch. Dihydropyrimidine dehydrogenase deficiency (DPD deficiency) is a condition in which there is absent or significantly decreased activity of dihydropyrimidine dehydrogenase. Individuals with this condition may develop life-threatening toxicity following exposure to 5-fluorouracil (5-FU), a chemotherapy drug that is used in the treatment of cancer.

Current research suggests that nearly 8% of the population has at least partial DPD deficiency. A diagnostics determination test for DPD deficiency is available and it is expected that with a potential 500,000 people in North America using 5-FU this form of testing will increase.

For a thorough scientific overview of Dihydropyrimidine dehydrogenase deficiency, one can consult chapter 91 of OMMBID^[1]. For more online resources and references, see inborn errors of metabolism.

References

• van Kuilenburg A (2006). "Screening for dihydropyrimidine dehydrogenase deficiency: to do or not to do, that's the question.". Cancer Invest 24 (2): 215-7. PMID 16537192.
• Lee A, Ezzeldin H, Fourie J, Diasio R (2004). "Dihydropyrimidine dehydrogenase deficiency: impact of pharmacogenetics on 5-Fluorouracil therapy.". Clin Adv Hematol Oncol 2 (8): 527-32. PMID 16163233.

External links

• Online 'Mendelian Inheritance in Man' (OMIM) 274270
• dpd genotype testing (www.mdl-labs.com)
• DPD deficiency website (sells tests)

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Articles on Dihydropyrimidine dehydrogenase deficiency	Most recent articles on Dihydropyrimidine dehydrogenase deficiency • Most cited articles on Dihydropyrimidine dehydrogenase deficiency • Review articles on Dihydropyrimidine dehydrogenase deficiency • Articles on Dihydropyrimidine dehydrogenase deficiency in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Dihydropyrimidine dehydrogenase deficiency	Powerpoint slides on Dihydropyrimidine dehydrogenase deficiency • Images of Dihydropyrimidine dehydrogenase deficiency • Photos of Dihydropyrimidine dehydrogenase deficiency • Podcasts & MP3s on Dihydropyrimidine dehydrogenase deficiency • Videos on Dihydropyrimidine dehydrogenase deficiency
Evidence Based Medicine Regarding Dihydropyrimidine dehydrogenase deficiency	Cochrane Collaboration on Dihydropyrimidine dehydrogenase deficiency • Bandolier on Dihydropyrimidine dehydrogenase deficiency • TRIP on Dihydropyrimidine dehydrogenase deficiency
Cost Effectiveness of Dihydropyrimidine dehydrogenase deficiency	Cost Effectiveness of Dihydropyrimidine dehydrogenase deficiency
Clinical Trials Involving Dihydropyrimidine dehydrogenase deficiency	Ongoing Trials on Dihydropyrimidine dehydrogenase deficiency at Clinical Trials.gov • Trial results on Dihydropyrimidine dehydrogenase deficiency • Clinical Trials on Dihydropyrimidine dehydrogenase deficiency at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Dihydropyrimidine dehydrogenase deficiency	US National Guidelines Clearinghouse on Dihydropyrimidine dehydrogenase deficiency • NICE Guidance on Dihydropyrimidine dehydrogenase deficiency • NHS PRODIGY Guidance • FDA on Dihydropyrimidine dehydrogenase deficiency • CDC on Dihydropyrimidine dehydrogenase deficiency
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Pharmacology Resources on Dihydropyrimidine dehydrogenase deficiency	Dosing of Dihydropyrimidine dehydrogenase deficiency • Drug interactions with Dihydropyrimidine dehydrogenase deficiency • Side effects of Dihydropyrimidine dehydrogenase deficiency • Allergic reactions to Dihydropyrimidine dehydrogenase deficiency • Overdose information on Dihydropyrimidine dehydrogenase deficiency • Carcinogenicity information on Dihydropyrimidine dehydrogenase deficiency • Dihydropyrimidine dehydrogenase deficiency in pregnancy • Pharmacokinetics of Dihydropyrimidine dehydrogenase deficiency •
Genetics, Pharmacogenomics, and Proteinomics of Dihydropyrimidine dehydrogenase deficiency	Genetics of Dihydropyrimidine dehydrogenase deficiency • Pharmacogenomics of Dihydropyrimidine dehydrogenase deficiency • Proteomics of Dihydropyrimidine dehydrogenase deficiency
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Healthcare Provider Resources on Dihydropyrimidine dehydrogenase deficiency	Symptoms of Dihydropyrimidine dehydrogenase deficiency • Causes & Risk Factors for Dihydropyrimidine dehydrogenase deficiency • Diagnostic studies for Dihydropyrimidine dehydrogenase deficiency • Treatment of Dihydropyrimidine dehydrogenase deficiency
Continuing Medical Education (CME) Programs on Dihydropyrimidine dehydrogenase deficiency	CME Programs on Dihydropyrimidine dehydrogenase deficiency
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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .