Diprenorphine

You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.

Image:Diprenorphine.png
Diprenorphine
Systematic (IUPAC) name
(5α,7α)-17-(Cyclopropylmethyl) -4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy -α,α-dimethyl-6,14-ethenomorphinan-7-methanol
Identifiers
CAS number	14357-78-9
ATC code	?
PubChem	443408
Chemical data
Formula	C26H35NO4
Mol. mass	425.56 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

WikiDoc Resources for Diprenorphine
Articles
Most recent articles on Diprenorphine Most cited articles on Diprenorphine Review articles on Diprenorphine Articles on Diprenorphine in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Diprenorphine Images of Diprenorphine Photos of Diprenorphine Podcasts & MP3s on Diprenorphine Videos on Diprenorphine
Evidence Based Medicine
Cochrane Collaboration on Diprenorphine Bandolier on Diprenorphine TRIP on Diprenorphine
Clinical Trials
Ongoing Trials on Diprenorphine at Clinical Trials.gov Trial results on Diprenorphine Clinical Trials on Diprenorphine at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Diprenorphine NICE Guidance on Diprenorphine NHS PRODIGY Guidance FDA on Diprenorphine CDC on Diprenorphine
Books
Books on Diprenorphine
News
Diprenorphine in the news Be alerted to news on Diprenorphine News trends on Diprenorphine
Commentary
Blogs on Diprenorphine
Definitions
Definitions of Diprenorphine
Patient Resources / Community
Patient resources on Diprenorphine Discussion groups on Diprenorphine Patient Handouts on Diprenorphine Directions to Hospitals Treating Diprenorphine Risk calculators and risk factors for Diprenorphine
Healthcare Provider Resources
Symptoms of Diprenorphine Causes & Risk Factors for Diprenorphine Diagnostic studies for Diprenorphine Treatment of Diprenorphine
Continuing Medical Education (CME)
CME Programs on Diprenorphine
International
Diprenorphine en Espanol Diprenorphine en Francais
Businness
Diprenorphine in the Marketplace Patents on Diprenorphine
Experimental / Informatics
List of terms related to Diprenorphine

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Diprenorphine (Revivon, M5050) is an opiate antagonist^[1] used to reverse the effects of the super-potent opioid analgesics such as etorphine and carfentanil that are used for tranquilizing large animals in veterinary medicine.

Diprenorphine is the strongest opiate antagonist that is commercially available (some 100 times more potent as an antagonist than nalorphine),^[1] and is used for reversing the effects of very strong opioids for which the binding affinity is so high that naloxone does not effectively or reliably reverse the narcotic effects.^[1] These super-potent opioids are not used in humans because the dose for a human is so small that it would be difficult to measure properly, so there is an excessive risk of overdose leading to fatal respiratory depression. However conventional opioid derivatives are not strong enough to rapidly tranquilize large animals such as elephants and rhinos, so drugs such as etorphine or carfentanil are available for this purpose.

Diprenorphine is considered the specific antagonist for etorphine and carfentanil,^[1] and is normally used to remobilise animals once veterinary procedures have been completed,^[1] however it may also be used on humans in the event that they are accidentally exposed to etorphine or carfentanil, for instance if someone working with large animals suffered a needlestick injury with a dart from a tranquiliser dart gun that was loaded with etorphine or carfentanil, they would be given diprenorphine as an antidote.

In theory diprenorphine could also be used as an antidote for treating overdose of certain opioid derivatives which are used in humans, such as buprenorphine, for which the binding affinity is so high that naloxone does not reliably reverse the narcotic effects. However diprenorphine is not generally available in hospitals, instead a vial of diprenorphine is supplied with the etorphine or carfentanil specifically for reversing the effects of these drugs, so use of diprenorphine for treating buprenorphine overdose is not carried out in practice although it would work in theory.

References

v • d • e Opioids (N02A)
Opiate derivatives	Whole Opium Preparations Dover's Powder • Granulated Opium • Laudanum • Mithridate • Opium • Paregoric • Poppy Straw Concentrate • Poppy tea • Powdered Opium • Raw Opium • Smoking Opium Natural Opiates Codeine • Morphine • Narceine • Noscapine • Omnopon • Oripavine • Pantopon • Papaveretum • Pseudomorphine • Tetrapon • Thebaine Semisynthetics 2,4-Dinitrophenylmorphine • 14-Hydroxyazidomorphine • 14-Ethoxymetopon • 14-Methoxymetopon • 14-Phenylpropoxymetopon • 6-Ketonalbuphine • 6-Methyldihydromorphine • 6-Methylenedihydrodesoxymorphine • 6-Methylene-14-hydroxydihydrodesoxymorphine • 8,14-Dihydroxydihydromorphinone • Acetylcodeine • Acetyldihydrocodeine • Acetylmorphone • Azidocodeine • Azidomorphine • Benzylmorphine • Chloromorphide • Clocinnamox • Codeine • Codeinone • Codorphone • Codoxime • Desocodeine • Desomorphine • Diacetyldihydromorphine • Dihydrocodeine • Dihydrocodeinone enol acetate • Dihydrohydroxycodeinone • Dihydrodesoxymorphine • Dihydroheroin • Dihydroheterocodeine • Dihydroisocodeine • Dihydromorphine • Dibutanoylmorphine • Dipropanoylmorphine • Ethyldihydromorphinone • Ethyldihydromorphine • Ethylmorphine • Heroin (Diamorphine) • Heroin-7,8-Oxide • Heterocodeine • Hydrocodone • Hydromorphinol • Hydromorphone • Isocodeine • Methyldesorphine • Methyldihydromorphine • Methylnaltrexone • Metopon • Morphinone • Myrophine • N-Phenethyl-14-ethoxymetopon • Nalbuphine • Nalfurafine • Nalmefene • Nalodeine • Nalorphine • Naloxone • Naltrexone • Naltrindole • Nicocodeine • Nicodicodeine • Nicomorphine • Oxycodone • Oxymorphone • Pholcodine • Semorphone • Thebacon Opiate metabolites Codeine-N-Oxide • Morphine-3-glucuronide • Morphine-6-glucuronide • Monoacetylmorphine • Morphine-N-Oxide • Naltrexol • Norcodeine • Normorphine
Morphinans	Aknadinine • Butorphanol • Cyclorphan • Cyprodime • Dextro-3-hydroxy-N-allylmorphinan • Dextromethorphan • Dextrorphan • Dimemorfan • Drotebanol • Levargorphan • Levallorphan • Levorphanol • Levorphan • Levophenacylmorphan • Levomethorphan • Norlevorphanol • Oxilorphan • Phenomorphan • Racemethorphan • Racemorphan • Salutaridine (Sinoacutine) • Sinococuline • Sinomenine (Cocculine)
Benzomorphans	5,9-DEHB • Anazocine • Bremazocine • Cogazocine • Cyclazocine • Dezocine • Eptazocine • Etazocine • Ethylketocyclazocine • Fluorophen • Ketazocine • Metazocine • Pentazocine • Phenazocine • Quadazocine • Thiazocine
4-Phenylpiperidines	Pethidines (Meperidines) Allylnorpethidine • Anileridine • Benzethidine • Carperidine • Difenoxin • Diphenoxylate • Etoxeridine (Carbetidine) • Furethidine • Hydroxypethidine (Bemidone) • Hydroxymethoxypethidine • Morpheridine • Oxpheneridine (Carbamethidine) • Meperidine-N-Oxide • Pethidine (Meperidine) • Pethidine Intermediate A • Pethidine Intermediate B (Norpethidine) • Pethidine Intermediate C (Pethidinic Acid) • Pheneridine • Phenoperidine • Piminodine • Properidine (Ipropethidine) • Sameridine Prodines Allylprodine • α-meprodine • α-prodine • β-meprodine • β-prodine • Isopromedol • Meprodine • MPPP • PEPAP • Prodine • Prosidol • Trimeperidine (Promedol) Ketobemidones Acetoxyketobemidone • Droxypropine • Ketobemidone • Methylketobemidone • Propylketobemidone Others Alvimopan • Loperamide • Picenadol
Open Chain Opioids	Amidones Dextromethadone • Dipipanone • Hexalgon • Isomethadone • Levomethadone • Methadone • Methadone intermediate • Normethadone • Norpipanone • Phenadoxone (Heptazone) • Pipidone Methadols Acetylmethadol • α-methadol • α-acetylmethadol • β-methadol • β-acetylmethadol • Dimepheptanol (Racemethadol) • Levo-α-acetylmethadol • Noracymethadol Moramides Dextromoramide • Levomoramide • Moramide intermediate • Racemoramide Thiambutenes Thiambutene • Diethylthiambutene • Dimethylthiambutene • Ethylmethylthiambutene • Tipepidine Phenalkoxams Dextropropoxyphene • Dimenoxadol • Dioxaphetyl Butyrate • Levopropoxyphene • Propoxyphene Ampromides Diampromide • Phenampromide • Propiram Others IC-26 • Lefetamine • R-4066
Anilidopiperidines	3-Allylfentanyl • 3-Methylfentanyl • 3-Methylthiofentanyl • Alfentanil • α-methylacetylfentanyl • α-methylfentanyl • α-methylthiofentanyl • Benzylfentanyl • β-hydroxyfentanyl • β-hydroxythiofentanyl • β-methylfentanyl • Brifentanil • Carfentanil • Fentanyl • Lofentanil • Mirfentanil • Ohmefentanyl • Parafluorofentanyl • Phenaridine • Remifentanil • Sufentanil • Thenylfentanyl • Thiofentanyl • Trefentanil
Oripavine derivatives	7-PET • Acetorphine • Alletorphine • BU-48 • Buprenorphine • Cyprenorphine • Dihydroetorphine • Diprenorphine • Etorphine • N-cyclopropylmethyl-noretorphine • Nepenthone • Norbuprenorphine • Thevinone
Phenazepines	Ethoheptazine • Meptazinol • Metheptazine • Metethoheptazine • Proheptazine
Pirinitramides	Bezitramide • Piritramide
Benzimidazoles	Clonitazene • Etonitazene
Indoles	7-Acetoxymitragynine • 7-Hydroxymitragynine • Akuammidine • Akuammine • Eseroline • Ibogaine • Mitragynine • ψ-Akuammigine
Diphenylmethylpiperazines	BW373U86 • DPI-221 • DPI-287 • DPI-3290 • SNC-80
Opioid Peptides	Casomorphin • DADLE • DALDA • DAMGO • Dermenkephalin • Dermorphin • Deltorphin • DPDPE • Dynorphin • Endomorphin • Endorphin • Enkephalin • TRIMU 5
Others	4-(p-Bromophenyl)-4-(dimethylamino)-1-phenethylcyclohexanol • C-8813 • Ciramadol • Enadoline • Faxeladol • Herkinorin • JTC-801 • Methopholine • NNC 63-0532 • Noscapine/Narcotine • O-Desmethyltramadol • Salvinorin A • RWJ-394,674 • Tapentadol • Tifluadom • Tilidine • Tramadol • Viminol • W-18 • Zipeprol
Narcotic Antagonists	5'-Guanidinonaltrindole • β-Funaltrexamine • Binaltorphimine • Cyclazocine • Cyclohexyl-alpha-phenethylallylamine • Diprenorphine • M5050 • Levallorphan • Nalmefene • Naloxazone • Naloxonazine • Naloxone • Nalorphine • Naltrexone • Naltrindole • Norbinaltorphimine • Oxilorphan

v • d • e WikiDoc Research Resources for Diprenorphine (Click show to right to view)
Articles on Diprenorphine	Most recent articles on Diprenorphine • Most cited articles on Diprenorphine • Review articles on Diprenorphine • Articles on Diprenorphine in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Diprenorphine	Powerpoint slides on Diprenorphine • Images of Diprenorphine • Photos of Diprenorphine • Podcasts & MP3s on Diprenorphine • Videos on Diprenorphine
Evidence Based Medicine Regarding Diprenorphine	Cochrane Collaboration on Diprenorphine • Bandolier on Diprenorphine • TRIP on Diprenorphine
Cost Effectiveness of Diprenorphine	Cost Effectiveness of Diprenorphine
Clinical Trials Involving Diprenorphine	Ongoing Trials on Diprenorphine at Clinical Trials.gov • Trial results on Diprenorphine • Clinical Trials on Diprenorphine at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Diprenorphine	US National Guidelines Clearinghouse on Diprenorphine • NICE Guidance on Diprenorphine • NHS PRODIGY Guidance • FDA on Diprenorphine • CDC on Diprenorphine
Textbook Information on Diprenorphine	Books and Textbook Information on Diprenorphine
Pharmacology Resources on Diprenorphine	Dosing of Diprenorphine • Drug interactions with Diprenorphine • Side effects of Diprenorphine • Allergic reactions to Diprenorphine • Overdose information on Diprenorphine • Carcinogenicity information on Diprenorphine • Diprenorphine in pregnancy • Pharmacokinetics of Diprenorphine •
Genetics, Pharmacogenomics, and Proteinomics of Diprenorphine	Genetics of Diprenorphine • Pharmacogenomics of Diprenorphine • Proteomics of Diprenorphine
Newstories on Diprenorphine	Diprenorphine in the news • Be alerted to news on Diprenorphine • News trends on Diprenorphine
Commentary on Diprenorphine	Blogs on Diprenorphine
Patient Resources on Diprenorphine	Patient resources on Diprenorphine • Discussion groups on Diprenorphine • Patient Handouts on Diprenorphine • Directions to Hospitals Treating Diprenorphine • Risk calculators and risk factors for Diprenorphine
Healthcare Provider Resources on Diprenorphine	Symptoms of Diprenorphine • Causes & Risk Factors for Diprenorphine • Diagnostic studies for Diprenorphine • Treatment of Diprenorphine
Continuing Medical Education (CME) Programs on Diprenorphine	CME Programs on Diprenorphine
International Resources on Diprenorphine	Diprenorphine en Espanol • Diprenorphine en Francais
Business Resources on Diprenorphine	Diprenorphine in the Marketplace • Patents on Diprenorphine
Informatics Resources on Diprenorphine	List of terms related to Diprenorphine

WikiDoc Help Menu Quick Start.. Get Started Here! How to Login How to Search Pages How to Start a New Page How to Edit a Page Cheat Sheet Editing basics Learning Basic Formatting How to make Links in WikiDoc & to External Sites How to Make Lists How to Ignoring Formatting Adding References or Footnotes to Articles Tracking Changes You Have Made How to Put an Article Into a Category When Multiple Topics Should Go To The Same Page (MI, Acute MI, AMI) Using Redirection Advanced editing How to Make Tables How to Insert Images and Other Media How to Add Video Help:How to Make Columns Web Colors How To Make Templates How to Move Pages Inserting Dynamic Dates and Times Inserting WikiDoc Statistics Editing the Table of Contents Communicating your edits Let others know what you changed: The importance of Edit Summaries Minor Edits Edit Conflicts Help Videos You Can Watch Getting Started Video

Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .