Dorzolamide
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| Image:Dorzolamide-2D-skeletal.png | |
| Image:Dorzolamide-3D-balls.png | |
| Dorzolamide
| |
| Systematic (IUPAC) name | |
| 2-ethylamino-4-methyl-5, 5-dioxo-5$l^{6}, 7-dithiabicyclo[4.3.0] nona-8,10- diene-8-sulfonamide | |
| Identifiers | |
| CAS number | 120279-96-1 |
| ATC code | S01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C10H16N2O4S3 |
| Mol. mass | 324.443 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | ~33% |
| Metabolism | ? |
| Half life | 4 months |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Dorzolamide is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent and topically applied in the form of eye drops. This drug was the first drug in human therapy (market introduction 1995) which resulted from structure-based drug design.
Trusopt (dorzolamide hydrochloride ophthalmic solution) is a carbonic anhydrase inhibitor formulated for topical ophthalmic use. Trusopt is used to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.
References
- Kubinyi H (1999). "Chance favors the prepared mind--from serendipity to rational drug design". J Recept Signal Transduct Res 19 (1-4): 15-39. PMID 10071748.
- Plummer C, MacKay E, Gelatt K. "Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs.". Vet Ophthalmol 9 (4): 245-9. PMID 16771760.
- Grover S, Apushkin M, Fishman G (2006). "Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa.". Am J Ophthalmol 141 (5): 850-8. PMID 16546110.
- Almeida G, Faria e Souza S (2006). "Effect of topical dorzolamide on rabbit central corneal thickness.". Braz J Med Biol Res 39 (2): 277-81. PMID 16470316.
External links
Ophthalmologicals: antiglaucoma preparations and miotics (S01E) | |
|---|---|
| Sympathomimetics | Apraclonidine • Brimonidine • Clonidine • Dipivefrine • Epinephrine |
| Parasympathomimetics | Aceclidine • Acetylcholine • Carbachol • Demecarium • Echothiophate • Stigmine (Fluostigmine, Neostigmine, Physostigmine) • Paraoxon • Pilocarpine |
| Carbonic anhydrase inhibitors | Acetazolamide • Brinzolamide • Diclofenamide • Dorzolamide • Methazolamide |
| Beta blocking agents | Befunolol • Betaxolol • Carteolol • Levobunolol • Metipranolol • Timolol |
| Prostaglandin analogues | Bimatoprost • Latanoprost • Travoprost • Unoprostone |
| Other agents | Dapiprazole • Guanethidine |
