Dromotropic
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A dromotropic agent is one which affects the conduction velocity of the AV node, and subsequently the rate of electrical impulses in the heart.[1][1]
Agents that are dromotropic are often (but not always) inotropic and chronotropic. For example, parasympathetic stimulation is usually negatively dromotropic, inotropic, and chronotropic.
Non-dihydropyridine calcium channel blockers such as verapamil block the slow inward calcium current in cardiac tissues thereby having a negatively dromotropic, chronotropic and inotropic effect[1]. This (and other) pharmacological effect makes these drugs useful in the treatment of angina pectoris. Conversely, they can lead to symptomatic disturbances in cardiac conduction and bradyarrhythmias, and may aggravate left ventricular failure[1].
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
