Reverse transcribing virus
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A reverse transcribing virus is any virus which replicates using reverse transcription, the formation of DNA from an RNA template. Both Group VI and Group VII viruses fall into this category. Group VI contains single-stranded RNA viruses which use a DNA intermediate to replicate, whereas Group VII contains double-stranded DNA viruses which use an RNA intermediate during genome replication.
Group VI
All members of Group VI use virally encoded reverse transcriptase, an RNA-dependent DNA polymerase, to produce DNA from the initial virion RNA genome. This DNA is often integrated into the host genome, as in the case of retroviruses and pseudoviruses, where it is replicated and transcribed by the host.
Group VI includes:
- Family Metaviridae
- Family Pseudoviridae
- Family Retroviridae - Retroviruses, e.g. HIV
Group VII
Both families in Group VII have DNA genomes contained within the invading virus particles. The DNA genome is transcribed into both mRNA, for use as a transcript in protein synthesis, and pre-genomic RNA, for use as the template during genome replication. Virally encoded reverse transcriptase uses the pre-genomic RNA as a template for the creation of genomic DNA.
Group VII includes:
- Family Hepadnaviridae - e.g. Hepatitis B virus
- Family Caulimoviridae - e.g. Cauliflower mosaic virus
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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
