Edward Lawrie Tatum
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| Data 2: | December 14, 1909 Boulder, Colorado, USA |
| Data 3 (data hidden if data3 empty or not defined): | November 05 1975 (aged 65) New York City, USA |
Edward Lawrie Tatum (December 14, 1909 – November 5, 1975) was an American geneticist. He shared half of the Nobel Prize in Physiology or Medicine in 1958 with George Wells Beadle for showing that genes control individual steps in metabolism. The other half of that year's award went to Joshua Lederberg.
Beadle and Tatum's key experiments involved exposing the bread mold Neurospora crassa to x-rays, causing mutations. In a series of experiments, they showed that these mutations caused changes in specific enzymes involved in metabolic pathways. These experiments, published in 1941, led them to propose a direct link between genes and enzymatic reactions, known as the "one gene, one enzyme" hypothesis.
Tatum went on to study genetics in bacteria. An active area of research in his laboratory was to understand the basis of Tryptophan biosynthesis in Escherichia coli. Later, Tatum and his student Lederberg showed that E. coli could share genetic information through recombination.
Tatum was born in Boulder, Colorado. He attended college at the University of Chicago and received his PhD in biochemistry from the University of Wisconsin-Madison in 1934. Starting in 1937, he worked at Stanford University, where he began his collaboration with Beadle. He then moved to Yale University in 1945 where he mentored Lederberg. He returned to Stanford in 1948 and then joined the faculty of Rockefeller Institute in 1957. A heavy cigarette smoker, he died in New York City of heart failure complicated by chronic emphysema.
References
- Nobel Lectures, Physiology or Medicine 1942-1962, Elsevier Publishing Company, Amsterdam, 1964
- Biographical Memoirs: National Academy of Sciences, Volume 59, National Academy Press, 1990
External links
| Persondata | |
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| NAME | Tatum, Edward Lawrie |
| ALTERNATIVE NAMES | |
| SHORT DESCRIPTION | genetics scientist |
| DATE OF BIRTH | 1909-12-14 |
| PLACE OF BIRTH | Boulder, Colorado |
| DATE OF DEATH | 1975-11-05 |
| PLACE OF DEATH | New York City |
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Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
