Amitriptyline
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Synonyms / Brand Names: Amitriptyline Hydrochloride, Amitriptyline HCL, Amitriprolidine, Amitriptylin, Amitryptiline, Amitryptyline, Amytriptiline, Adepress, Adepril, Amitid, Amitril, Damilan, Damilen, dAmitriptyline, Elanil, Elavil, Endep, Flavyl, Hexathane, Horizon, Lantron, Laroxil, Laroxyl, Lentizol, Proheptadiene, Redomex, Saroten, Sarotex, Seroten, Sylvemid, Triptanol, Triptilin, Triptisol, Tryptanol, Tryptizol
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-525-6884
Dosing and Administration
For outpatients, 75 mg of Amitriptyline HCl a day in divided doses is usually satisfactory. If necessary, this may be increased to a total of 150 mg per day. Increases are made preferably in the late afternoon and/or bedtime doses. A sedative effect may be apparent before the antidepressant effect is noted, but an adequate therapeutic effect may take as long as 30 days to develop.
An alternate method of initiating therapy in outpatients is to begin with 50 to 100 mg Amitriptyline HCl at bedtime. This may be increased by 25 or 50 mg as necessary in the bedtime dose to a total of 150 mg per day.
Hospitalized patients may require 100 mg a day initially. This can be increased gradually to 200 mg a day if necessary. A small number of hospitalized patients may need as much as 300 mg a day.
FDA Package Insert Resources
Indications, Contraindications, Side Effects, Drug Interactions, etc.
Calculate Creatine Clearance
On line calculator of your patients Cr Cl by a variety of formulas.
Convert pounds to Kilograms
On line calculator of your patients weight in pounds to Kg for dosing estimates.
Publication Resources
Recent articles, WikiDoc State of the Art Review, Textbook Information
Trial Resources
Ongoing Trials, Trial Results
Guidelines & Evidence Based Medicine Resources
US National Guidelines, Cochrane Collaboration, etc.
Media Resources
Slides, Video, Images, MP3, Podcasts, etc.
Patient Resources
Discussion Groups, Handouts, Blogs, News, etc.
International Resources
en Español
FDA Package Insert Resources
Indications
Contraindications
Side Effects
Drug Interactions
Precautions
Overdose
Instructions for Administration
How Supplied
Pharmacokinetics and Molecular Data
FDA label
FDA on Amitriptyline
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Publication Resources
Most Recent Articles on Amitriptyline
Review Articles on Amitriptyline
Articles on Amitriptyline in N Eng J Med, Lancet, BMJ
WikiDoc State of the Art Review
Textbook Information on Amitriptyline
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Trial Resources
Ongoing Trials with Amitriptyline at Clinical Trials.gov
Trial Results with Amitriptyline
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Guidelines & Evidence Based Medicine Resources
US National Guidelines Clearinghouse on Amitriptyline
Cochrane Collaboration on Amitriptyline
Cost Effectiveness of Amitriptyline
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Media Resources
Powerpoint Slides on Amitriptyline
Images of Amitriptyline
Podcasts & MP3s on Amitriptyline
Videos on Amitriptyline
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Patient Resources
Patient Information from National Library of Medicine
Patient Resources on Amitriptyline
Discussion Groups on Amitriptyline
Patient Handouts on Amitriptyline
Blogs on Amitriptyline
Amitriptyline in the News
Amitriptyline in the Marketplace
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International Resources
Amitriptyline en Español
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The content of this page is taken from the FDA package insert for this drug and should not be edited.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
