Endopeptidase
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Endopeptidase or endoproteinase are peptidases that break peptide bonds within the molecule, in contrast to exopeptidases, which break peptide bonds from their end-pieces. Thus, endopeptidases cleave peptides.
They are usually very specific for certain amino acids.
Examples of endopeptidases include:
- Trypsin - cuts after Arg or Lys, unless followed by Pro. Very strict.
- Chymotrypsin - cuts after Phe, Trp, or Tyr, unless followed by Pro. Cuts more slowly after Asn, His, Met or Leu.
- Elastase - cuts after Ala, Gly, Ser, or Val, unless followed by Pro.
- Thermolysin - cuts before Ile, Met, Phe, Trp, Tyr, or Val, unless preceded by Pro. Sometimes cuts after Ala, Asp, His or Thr. Heat stable.
- Pepsin - cuts before Leu, Phe, Trp or Tyr, unless preceded by Pro. Also others, quite nonspecific; works best at pH 2.
- Endopeptidase V8 - cuts after Glu.
See also
External links
Hydrolase: proteases (EC 3.4) | |
|---|---|
| Exopeptidase 3.4.11-19 | Angiotensin-converting enzyme - Dipeptidase - Dipeptidyl peptidase-4 - DD-transpeptidase Metalloexopeptidases: Aminopeptidase (Alanine, Cystinyl, Leucyl, Glutamyl) - Carboxypeptidase (A, B, C, E, Glutamate II) |
| Endopeptidase 3.4.21-24 | Serine proteases - Cysteine protease - Aspartic acid protease - Metalloendopeptidases |
| Cathepsin 3.4.18,21,22,23 | A - B - C - K |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
