Epibatidine
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| Epibatidine | |
|---|---|
| Image:Epibatidine structure.png | |
| IUPAC name | (4S,6R)-6-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptane |
| Identifiers | |
| CAS number | |
| PubChem | |
| MeSH | |
| SMILES | C1CC2C(CC1N2)C3=CN=C(C=C3)Cl |
| Properties | |
| Molecular formula | C11H13ClN2 |
| Molar mass | 208.687 |
| Melting point |
59-66 °C |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references | |
Epibatidine is an alkaloid that originally is found in the skin of a neotropical poisonous frog, Epipedobates tricolor, found in modern Ecuador. It was initially isolated by John Daly at the National Institutes of Health, and was found to be a powerful analgesic, about 200 times more potent than morphine.[1] Because the natural source of epibatidine can only supply a small quantity, several laboratory syntheses have been developed.[1]
Interestingly, the compound is not an opioid; instead, it is similar to nicotine and appears to act by binding and activating nicotinic acetylcholine receptors. While epibatidine may be too toxic to use in clinical practice, the compound represents a new lead in the drug design of new analgesics.[1]
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
