Factor VII

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Coagulation factor VII (serum prothrombin conversion accelerator)
Anchoring of coagulation factor VIIa to the mebrane through its Gla domain
Identifiers
Symbol(s)	F7;
External IDs	OMIM: 227500 MGI: 109325 Homologene: 7710
Gene ontology Molecular Function: • coagulation factor VIIa activity • serine-type endopeptidase activity • calcium ion binding Cellular Component: • extracellular region Biological Process: • proteolysis • blood coagulation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	2155	14068
Ensembl	ENSG00000057593	ENSMUSG00000031443
Uniprot	P08709	Q542C2
Refseq	NM_000131 (mRNA) NP_000122 (protein)	NM_010172 (mRNA) NP_034302 (protein)
Location	Chr 13: 112.81 - 112.82 Mb	Chr 8: 13.03 - 13.04 Mb
Pubmed search	[1]	[2]

WikiDoc Resources for Factor VII
Articles
Most recent articles on Factor VII Most cited articles on Factor VII Review articles on Factor VII Articles on Factor VII in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Factor VII Images of Factor VII Photos of Factor VII Podcasts & MP3s on Factor VII Videos on Factor VII
Evidence Based Medicine
Cochrane Collaboration on Factor VII Bandolier on Factor VII TRIP on Factor VII
Clinical Trials
Ongoing Trials on Factor VII at Clinical Trials.gov Trial results on Factor VII Clinical Trials on Factor VII at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Factor VII NICE Guidance on Factor VII NHS PRODIGY Guidance FDA on Factor VII CDC on Factor VII
Books
Books on Factor VII
News
Factor VII in the news Be alerted to news on Factor VII News trends on Factor VII
Commentary
Blogs on Factor VII
Definitions
Definitions of Factor VII
Patient Resources / Community
Patient resources on Factor VII Discussion groups on Factor VII Patient Handouts on Factor VII Directions to Hospitals Treating Factor VII Risk calculators and risk factors for Factor VII
Healthcare Provider Resources
Symptoms of Factor VII Causes & Risk Factors for Factor VII Diagnostic studies for Factor VII Treatment of Factor VII
Continuing Medical Education (CME)
CME Programs on Factor VII
International
Factor VII en Espanol Factor VII en Francais
Businness
Factor VII in the Marketplace Patents on Factor VII
Experimental / Informatics
List of terms related to Factor VII

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Factor VII (formerly known as proconvertin) is one of the central proteins in the coagulation cascade. It is an enzyme (EC 3.4.21.21) of the serine protease class.

Physiology

The main role of factor VII (FVII) is to initiate the process of coagulation in conjunction with tissue factor (TF). Tissue factor is found on the outside of blood vessels - normally not exposed to the bloodstream. Upon vessel injury, tissue factor is exposed to the blood and circulating factor VII. Once bound to TF, FVII is activated to FVIIa by different proteases, among which are thrombin (factor IIa), activated factor X and the FVIIa-TF complex itself. The most important substrates for FVIIa-TF are Factor X and Factor IX.

The action of the factor is impeded by tissue factor pathway inhibitor (TFPI), which is released almost immediately after initiation of coagulation. Factor VII is vitamin K dependent; it is produced in the liver. Use of warfarin or similar anticoagulants impairs its function.

Genetics

The gene for factor VII is located on chromosome 13 (13q34).

Role in disease

Deficiency is rare (congenital proconvertin deficiency) and inherits recessively.

Therapeutic use

Recombinant human factor VIIa (NovoSeven®, eptacog alfa [activated], ATC code B02BD08) has been introduced for use in uncontrollable bleeding in hemophilia patients (with Factor VIII or IX deficiency) who have developed inhibitors against replacement coagulation factor.

It is being increasingly used in uncontrollable hemorrhage.^[1] The first report of its use was in an Israeli soldier with uncontrollable bleeding in 1999.^[1] The rationale for its use in hemorrhage is, that it will only induce coagulation in those sites where tissue factor (TF) is also present. Still, O'Connell et al report an increased risk of deep vein thrombosis, pulmonary embolism and myocardial infarction in association with the use of rhFVIIa.^[1]

According to a 2005 study, recombinant human factor VII improves outcomes in acute intracerebral hemorrhage.^[1]

References

External links

• Web site for novoseven-us.com

Further reading

v • d • e Proteins: coagulation
Coagulation factors	intrinsic pathway (FXII, FXI, FIX, FVIII) - extrinsic pathway (Tissue factor, FVII) - common pathway (FX, FV, (Pro)thrombin / FII, Fibrin / FI, FXIII) - HMWK - vWF - Kallikrein
Inhibitors	Antithrombin - Protein C - Protein S - Protein Z - ZPI - TFPI
Fibrinolysis	Plasmin - tPA/urokinase - PAI-1/2 - α2-AP - α2-macroglobulin - TAFI

v • d • e Antihemorrhagics (B02)
Antifibrinolytics	amino acids (Aminocaproic acid, Tranexamic acid, Aminomethylbenzoic acid) - serpins (Aprotinin, Alfa1 antitrypsin, C1-inhibitor, Camostat)
Vitamin K	Phytomenadione - Menadione
Fibrinogen	Fibrinogen
Local hemostatics	Absorbable gelatin sponge - Oxidized cellulose - Tetragalacturonic acid hydroxymethylester - Adrenalone - Thrombin - Collagen - Calcium alginate - Epinephrine
Blood coagulation factors	IX - II - VII - X - VIII - Eptacog alfa - Nonacog alfa - Thrombin
Other systemic hemostatics	Etamsylate - Carbazochrome - Batroxobin

v • d • e WikiDoc Research Resources for Factor VII (Click show to right to view)
Articles on Factor VII	Most recent articles on Factor VII • Most cited articles on Factor VII • Review articles on Factor VII • Articles on Factor VII in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Factor VII	Powerpoint slides on Factor VII • Images of Factor VII • Photos of Factor VII • Podcasts & MP3s on Factor VII • Videos on Factor VII
Evidence Based Medicine Regarding Factor VII	Cochrane Collaboration on Factor VII • Bandolier on Factor VII • TRIP on Factor VII
Cost Effectiveness of Factor VII	Cost Effectiveness of Factor VII
Clinical Trials Involving Factor VII	Ongoing Trials on Factor VII at Clinical Trials.gov • Trial results on Factor VII • Clinical Trials on Factor VII at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Factor VII	US National Guidelines Clearinghouse on Factor VII • NICE Guidance on Factor VII • NHS PRODIGY Guidance • FDA on Factor VII • CDC on Factor VII
Textbook Information on Factor VII	Books and Textbook Information on Factor VII
Pharmacology Resources on Factor VII	Dosing of Factor VII • Drug interactions with Factor VII • Side effects of Factor VII • Allergic reactions to Factor VII • Overdose information on Factor VII • Carcinogenicity information on Factor VII • Factor VII in pregnancy • Pharmacokinetics of Factor VII •
Genetics, Pharmacogenomics, and Proteinomics of Factor VII	Genetics of Factor VII • Pharmacogenomics of Factor VII • Proteomics of Factor VII
Newstories on Factor VII	Factor VII in the news • Be alerted to news on Factor VII • News trends on Factor VII
Commentary on Factor VII	Blogs on Factor VII
Patient Resources on Factor VII	Patient resources on Factor VII • Discussion groups on Factor VII • Patient Handouts on Factor VII • Directions to Hospitals Treating Factor VII • Risk calculators and risk factors for Factor VII
Healthcare Provider Resources on Factor VII	Symptoms of Factor VII • Causes & Risk Factors for Factor VII • Diagnostic studies for Factor VII • Treatment of Factor VII
Continuing Medical Education (CME) Programs on Factor VII	CME Programs on Factor VII
International Resources on Factor VII	Factor VII en Espanol • Factor VII en Francais
Business Resources on Factor VII	Factor VII in the Marketplace • Patents on Factor VII
Informatics Resources on Factor VII	List of terms related to Factor VII

ca:Factor VII

de:Proconvertinsv:Faktor VII

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .