Erythroleukemia

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Erythroleukemia Classification and external resources
Erythroleukemia: Nucleated Red Cells and Erythroblasts Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology
ICD-10	C94.0
ICD-9	207.0
ICD-O:	M9840/3
OMIM	133180
eMedicine	med/729
MeSH	D004915

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Media
Powerpoint slides on Erythroleukemia Images of Erythroleukemia Photos of Erythroleukemia Podcasts & MP3s on Erythroleukemia Videos on Erythroleukemia
Evidence Based Medicine
Cochrane Collaboration on Erythroleukemia Bandolier on Erythroleukemia TRIP on Erythroleukemia
Clinical Trials
Ongoing Trials on Erythroleukemia at Clinical Trials.gov Trial results on Erythroleukemia Clinical Trials on Erythroleukemia at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Erythroleukemia NICE Guidance on Erythroleukemia NHS PRODIGY Guidance FDA on Erythroleukemia CDC on Erythroleukemia
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Books on Erythroleukemia
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Erythroleukemia in the news Be alerted to news on Erythroleukemia News trends on Erythroleukemia
Commentary
Blogs on Erythroleukemia
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Definitions of Erythroleukemia
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Patient resources on Erythroleukemia Discussion groups on Erythroleukemia Patient Handouts on Erythroleukemia Directions to Hospitals Treating Erythroleukemia Risk calculators and risk factors for Erythroleukemia
Healthcare Provider Resources
Symptoms of Erythroleukemia Causes & Risk Factors for Erythroleukemia Diagnostic studies for Erythroleukemia Treatment of Erythroleukemia
Continuing Medical Education (CME)
CME Programs on Erythroleukemia
International
Erythroleukemia en Espanol Erythroleukemia en Francais
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Experimental / Informatics
List of terms related to Erythroleukemia

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Overview

Erythroleukemia (or "acute Di Guglielmo syndrome") is a rare form of acute myeloid leukemia where the myeloproliferation is of erythrocyte precursors.

It is defined at type "M6" under the FAB classification.^[1]

Types

It can be classified as follows:

• M6a; Erythroid/Myeloid

• M6b; Pure Erythroid Malignancy

Criteria for diagnosis of M6

M6a

50% or more of all nucleated bone marrow cells are erythroblasts, Dyserythropoiesis is prominent and 30% or more of the remaining cells (non- erythroid) are myeloblasts.

M6b ( Pure Erythroid Malignancy )

In rare cases the erythroid lineage is the only obvious components of an acute leukemia; a myeloblast component is not apparent. The erythroid component consists predominantly or exclusively of proerythroblasts and early basophilic erythroblasts. These cells may constitute 90% or more of the marrow elements. Despite this lack of myeloblast, these cases should be considered acute leukemias. In WHO proposal the blastic leukeimas that are limited to the erythroid series are designated pure erythroid malignancy.

References

Kowal-Vern A, Mazzella FM, Cotelingam JD, Shrit MA, Rector JT, Schumacher HR (2000). "Diagnosis and characterization of acute erythroleukemia subsets by determining the percentages of myeloblasts and proerythroblasts in 69 cases". Am. J. Hematol. 65 (1): 5-13. PMID 10936857.

External links

• Atlas of Acute Leukemia

v • d • e Pathology: hematology, myeloid hematologic disease (primarily D50-D77, 280-289)
RBCs/ hemoglobinopathy	+ Polycythemia - Macrocytosis - Anemia Nutritional Iron deficiency anemia (Plummer-Vinson syndrome), Megaloblastic anemia (Pernicious anemia) Hemolytic Hereditary enzyme: G6PD Deficiency - Pyruvate kinase deficiency - Triosephosphate isomerase deficiency hemoglobin: Thalassemia - Sickle-cell disease/trait membrane: Hereditary spherocytosis - Hereditary elliptocytosis - Hereditary stomatocytosis Acquired Autoimmune (Warm, Cold), HUS, MAHA, PNH, PCH, Myelophthisic Aplastic Acquired PRCA, Diamond-Blackfan anemia, Fanconi anemia, Sideroblastic anemia Blood tests Normocytic - Microcytic - Macrocytic - Normochromic - Hypochromic Other Methemoglobinemia
Coagulation/platelets/ coagulopathy/ bleeding diathesis	+ Hypercoagulability primary: Antithrombin III deficiency - Protein C deficiency/Activated protein C resistance/Protein S deficiency/Factor V Leiden - Hyperprothrombinemia acquired: DIC (Congenital afibrinogenemia, Purpura fulminans) - autoimmune (Antiphospholipid) Other Essential thrombocytosis - clotting factor: Hemophilia (A/VIII, B/IX, C/XI) • Von Willebrand disease • Hypoprothrombinemia/II - XIII platelet function: Bernard-Soulier syndrome - Glanzmann's thrombasthenia - Gray platelet syndrome - May Hegglin anomaly - Pelger-Huet anomaly Purpura: Henoch-Schönlein, ITP (Evans syndrome), TTP Thrombocytopenia (Heparin-induced thrombocytopenia)
Monocytes/ macrophages	+ Histiocytosis WHO-I (Langerhans cell histiocytosis) WHO-II/non-Langerhans-cell (Juvenile xanthogranuloma, Hemophagocytic lymphohistiocytosis) WHO-III/malignant (Acute monocytic leukemia, Malignant histiocytosis, Erdheim-Chester disease) Other Chronic granulomatous disease -cytosis: Monocytosis - -penia: Monocytopenia
Granulocytes	+ -cytosis: granulocytosis (Neutrophilia, Eosinophilia, Basophilia) - -penia: Granulocytopenia/agranulocytosis (Neutropenia, Kostmann syndrome)
See also hematological malignancy and immune disorders

v • d • e WikiDoc Research Resources for Erythroleukemia (Click show to right to view)
Articles on Erythroleukemia	Most recent articles on Erythroleukemia • Most cited articles on Erythroleukemia • Review articles on Erythroleukemia • Articles on Erythroleukemia in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Erythroleukemia	Powerpoint slides on Erythroleukemia • Images of Erythroleukemia • Photos of Erythroleukemia • Podcasts & MP3s on Erythroleukemia • Videos on Erythroleukemia
Evidence Based Medicine Regarding Erythroleukemia	Cochrane Collaboration on Erythroleukemia • Bandolier on Erythroleukemia • TRIP on Erythroleukemia
Cost Effectiveness of Erythroleukemia	Cost Effectiveness of Erythroleukemia
Clinical Trials Involving Erythroleukemia	Ongoing Trials on Erythroleukemia at Clinical Trials.gov • Trial results on Erythroleukemia • Clinical Trials on Erythroleukemia at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Erythroleukemia	US National Guidelines Clearinghouse on Erythroleukemia • NICE Guidance on Erythroleukemia • NHS PRODIGY Guidance • FDA on Erythroleukemia • CDC on Erythroleukemia
Textbook Information on Erythroleukemia	Books and Textbook Information on Erythroleukemia
Pharmacology Resources on Erythroleukemia	Dosing of Erythroleukemia • Drug interactions with Erythroleukemia • Side effects of Erythroleukemia • Allergic reactions to Erythroleukemia • Overdose information on Erythroleukemia • Carcinogenicity information on Erythroleukemia • Erythroleukemia in pregnancy • Pharmacokinetics of Erythroleukemia •
Genetics, Pharmacogenomics, and Proteinomics of Erythroleukemia	Genetics of Erythroleukemia • Pharmacogenomics of Erythroleukemia • Proteomics of Erythroleukemia
Newstories on Erythroleukemia	Erythroleukemia in the news • Be alerted to news on Erythroleukemia • News trends on Erythroleukemia
Commentary on Erythroleukemia	Blogs on Erythroleukemia
Patient Resources on Erythroleukemia	Patient resources on Erythroleukemia • Discussion groups on Erythroleukemia • Patient Handouts on Erythroleukemia • Directions to Hospitals Treating Erythroleukemia • Risk calculators and risk factors for Erythroleukemia
Healthcare Provider Resources on Erythroleukemia	Symptoms of Erythroleukemia • Causes & Risk Factors for Erythroleukemia • Diagnostic studies for Erythroleukemia • Treatment of Erythroleukemia
Continuing Medical Education (CME) Programs on Erythroleukemia	CME Programs on Erythroleukemia
International Resources on Erythroleukemia	Erythroleukemia en Espanol • Erythroleukemia en Francais
Business Resources on Erythroleukemia	Erythroleukemia in the Marketplace • Patents on Erythroleukemia
Informatics Resources on Erythroleukemia	List of terms related to Erythroleukemia

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .