Estradiol side effects
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-525-6884
List of Side Effects
Genitourinary system
Breasts
Cardiovascular
Gastrointestinal
Skin
Eyes
Central nervous system
Miscellaneous
Genitourinary system
- Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flow; breakthrough bleeding, spotting, dysmenorrhea
- Increase in size of uterine leiomyomata
- Vaginitis, including vaginal candidiasis
- Change in amount of cervical secretion
- Changes in cervical ectropion
- Ovarian cancer; endometrial hyperplasia; endometrial cancer Return to top
Breasts
Tenderness, enlargement, pain, nipple discharge, galactorrhea; fibrocystic breast changes; breast cancer. Return to top
Cardiovascular
Deep and superficial venous thrombosis; pulmonary embolism; thrombophlebitis; myocardial infarction; stroke; increase in blood pressure. Return to top
Gastrointestinal
- Nausea, vomiting
- Abdominal cramps, bloating
- Cholestatic jaundice
- Increased incidence of gallbladder disease
- Pancreatitis
- Enlargement of hepatic hemangiomas. Return to top
Skin
- Chloasma or melasma that may persist when drug is discontinued
- Erythema multiforme
- Erythema nodosum
- Hemorrhagic eruption
- Loss of scalp hair
- Hirsutism
- Pruritus, rash. Return to top
Eyes
- Retinal vascular thrombosis
- Steepening of corneal curvature
- Intolerance to contact lenses. Return to top
Central nervous system
- Headache, migraine, dizziness
- Mental depression
- Chorea
- Nervousness, mood disturbances, irritability
- Exacerbation of epilepsy
- Dementia. Return to top
Miscellaneous
- Increase or decrease in weight
- Reduced carbohydrate tolerance
- Aggravation of porphyria
- Edema
- Arthralgias; leg cramps
- Changes in libido
- Urticaria
- Angioedema
- Anaphylactoid/anaphylactic reactions
- Hypocalcemia
- Exacerbation of asthma
- Increased triglycerides. Return to top
The content of this page is taken from the FDA package insert for this drug and should not be edited.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
