Estrone
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| Estrone
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| Systematic (IUPAC) name | |
| 3-hydroxy-13-methyl- 6,7,8,9,11,12,13,14,15,16- decahydrocyclopenta[a]phenanthren- 17- one | |
| Identifiers | |
| CAS number | |
| ATC code | G03 G03CC04 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C18H22O2 |
| Mol. mass | 270.366 g/mol |
| Physical data | |
| Melt. point | 254.5 °C (490 °F) |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Protein binding | >95% |
| Metabolism | ? |
| Half life | 19 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | ? |
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US National Guidelines Clearinghouse on Estrone
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Estrone (also oestrone) is an estrogenic hormone secreted by the ovary.
Estrone is one of the three estrogens, which also include estriol and estradiol. Estrone is the least prevalent of the three hormones, estradiol being prevalent almost always in a female body, estriol being prevalent primarily during pregnancy. Estrone is relevant to health and disease due to its conversion to estrone sulfate, a long-lived derivative of estrone. Estrone sulfate acts as a pool of estrone which can be converted as needed to the more active estradiol.
Synthesis
Estrone is synthesized via aromatase from androstenedione, a derivative of progesterone. The conversion consists of the de-methylation of C-19 and the aromaticity of the 'A' ring. This reaction is similar to the conversion of testosterone to estradiol.
Additional images
 Androstenedione converting to estrone. |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
