Ethisterone
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| Ethisterone
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| Systematic (IUPAC) name | |
| 17-ethynyl-17-hydroxy-10,13-dimethyl-2,6,7,8,9, 11,12,14,15,16-decahydro-1H- cyclopenta[a]phenanthren-3-one | |
| Identifiers | |
| CAS number | |
| ATC code | G03 |
| PubChem | |
| Chemical data | |
| Formula | C21H28O2 |
| Mol. mass | 312.446 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
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| Routes | ? |
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Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Ethisterone is a progestogen hormone. The first orally active progestin, ethisterone (pregneninolone, 17α-ethynyltestosterone), the 17α-ethynyl analog of testosterone, was synthesized in 1938 by Hans Herloff Inhoffen, Willy Logemann, Walter Hohlweg, and Arthur Serini at Schering AG in Berlin and marketed in Germany in 1939 as Proluton C and by Schering in the U.S. in 1945 as Pranone. Ethisterone was also marketed in the U.S. from the 1950s into the 1960s under a variety of trade names by other pharmaceutical companies that had been members of the pre-World War II European hormone cartel(Ciba, Organon, Roussel).
References
- Inhoffen HH, Logemann W, Hohlweg W, Serini A (May 4, 1938). "Untersuchungen in der Sexualhormon-Reihe (Investigations in the sex hormone series)". Ber Dtsch Chem Ges 71 (5): 1024-32.
- Petrow V (1970). "The contraceptive progestagens". Chem Rev 70 (6): 713-26. PMID 4098492.
- Kugener, André (2004). Tabletten der Fa. Schering (Tablets of Schering AG) Proluton C tablets circa 1939
- Quinkert G (2004). "Hans Herloff Inhoffen in His Times (1906-1992)". Eur J Org Chem 2004 (17): 3727-48.
- Sneader, Walter (2005). "Hormone analogues", Drug discovery : a history. Hoboken NJ: John Wiley & Sons, pp. 188-225. ISBN 0-471-89980-1.
- Djerassi C (2006). "Chemical birth of the pill". Am J Obstet Gynecol 194 (1): 290-8. PMID 16389046.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
