FcεRI
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| Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
| |
| Identifiers | |
| Symbol | FCER1A |
| Alt. Symbols | FCE1A |
| Entrez | 2205 |
| HUGO | 3609 |
| OMIM | 147140 |
| RefSeq | NM_002001 |
| UniProt | P12319 |
| Other data | |
| Locus | Chr. 1 q23 |
| membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
| |
| Identifiers | |
| Symbol | MS4A2 |
| Alt. Symbols | FCER1B, IGER, APY |
| Entrez | 2206 |
| HUGO | 7316 |
| OMIM | 147138 |
| RefSeq | NM_000139 |
| UniProt | Q01362 |
| Other data | |
| Locus | Chr. 1 q23 |
| Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
| |
| Identifiers | |
| Symbol | FCER1G |
| Entrez | 2207 |
| HUGO | 3611 |
| OMIM | 147139 |
| RefSeq | NM_004106 |
| UniProt | P30273 |
| Other data | |
| Locus | Chr. 1 q23 |
FcεRI, or Fc epsilon RI, is the high-affinity receptor for immunoglobulin E (IgE), an antibody isotype involved in allergy and resistance to parasites. FcεRI is a tetrameric receptor complex consisting of one alpha (FcεRIα), one beta (FcεRIβ), and two gamma chains (FcεRIγ). It is expressed predominantly on mast cells and basophils.
Crosslinking of the FcεRI via IgE-allergen complexes leads to degranulation of mast cells or basophils and release of inflammatory mediators. At laboratory conditions degranulation of isolated basophils can also be induced with antibodies to the FcεRIα which crosslink the receptor. Such crosslinking and potentially pathogenic autoantibodies to the FcεRIα have been isolated from human cord blood, which suggest that they occur naturally and are present already at birth. However, their epitope on FcεRIα was masked by IgE and the affinity of the corresponding autoantibodies found in healthy adults appeared lowered.[1]
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References
External links
Transmembrane receptors: immune receptors | |
|---|---|
| Cytokine receptor | Type I: interleukin (IL-2, IL-3) - CSF (Erythropoietin, GM-CSF, G-CSF) - Glycoprotein 130/Oncostatin M - Leukemia inhibitory factor - common subunits (Common gamma chain, CSF2RB) Type II: interleukin (IL22RA2) - interferon (IFNAR, IFNGR) |
| Pattern recognition/Toll-like | TLR 1 - TLR 2 - TLR 3 - TLR 4 - TLR 5 - TLR 6 - TLR 7 - TLR 8 - TLR 9 - TLR 10 |
| Fc receptor | ε (FcεRI, FcεRII) - γ (FcγRI, FcγRII, FcγRIII) - α/μ (FcαRI, Fcα/μR) - Neonatal |
| Lymphocyte homing receptor | CD44 - L-selectin - VLA-4 - LFA-1 |
| other | Antigen receptor (B-cell, T cell) - Complement - Formyl peptide - Immunophilins - Integrin - Killer-cell immunoglobulin-like - Scavenger |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
