Fenoldopam
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| Fenoldopam
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| Systematic (IUPAC) name | |
| 8-chloro-2-(4-hydroxyphenyl)- 4-azabicyclo[5.4.0] undeca-7,9,11-triene-9,10-diol | |
| Identifiers | |
| CAS number | |
| ATC code | C01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C16H16ClNO3 |
| Mol. mass | 305.756 g/mol |
| Pharmacokinetic data | |
| Bioavailability | n/a |
| Metabolism | Hepatic (CYP not involved) |
| Half life | 5 minutes |
| Excretion | Renal (90%) and fecal (10%) |
| Therapeutic considerations | |
| Licence data |
|
| Pregnancy cat. |
B(US) |
| Legal status | |
| Routes | Intravenous |
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Overview
Fenoldopam is a synthetic compound that acts as a selective peripheral dopamine D1A receptor agonist. Fenoldopam is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation, decreasing afterload and also through specific dopamine receptors along the nephron promoting sodium excretion.
Anti-parkinson drugs: dopaminergic agents (N04B) | |
|---|---|
| Dopa and derivatives | Levodopa, Melevodopa, Etilevodopa |
| Adamantane derivatives | Amantadine |
| Dopamine agonists | Apomorphine, Bromocriptine, Cabergoline, Dihydrexidine, Dihydroergocryptine mesylate, Fenoldopam, Lisuride, Pergolide, Piribedil, Pramipexole, Quinpirole, Ropinirole, Rotigotine, SKF 38393, SKF 82958 |
| MAOIs | Selegiline, Rasagiline |
| Other | Tolcapone, Entacapone, Budipine |
Cardiac stimulants excluding cardiac glycosides (C01C) | |
|---|---|
| Adrenergic and dopaminergic agents | Etilefrine • Isoprenaline • Norepinephrine • Dopamine • Norfenefrine • Phenylephrine • Dobutamine • Oxedrine • Metaraminol • Methoxamine • Mephentermine • Dimetofrine • Prenalterol • Dopexamine • Gepefrine • Ibopamine • Midodrine • Octopamine • Fenoldopam • Cafedrine • Arbutamine • Theodrenaline • Epinephrine |
| Phosphodiesterase inhibitors (PDE3I) | Amrinone • Milrinone • Enoximone • Bucladesine |
| Other cardiac stimulants | Angiotensinamide • Xamoterol • Levosimendan |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
