Fiber diffraction
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Overview
Fiber diffraction is a scattering technique in which molecular structure is determined from scattering data (usually of X-rays or electrons) from filaments composed of a regular array of molecules distinguished by a single direction (the fiber axis). The resulting diffraction patterns show layer lines, each with Bessel function intensities.
Historical role
Fiber diffraction data led to several important advances in the development of structural biology, e.g., the original models of the α-helix and the Watson-Crick model of double-stranded DNA.
References
- Cochran W, Crick FHC, and Vand V (1952). "The Structure of Synthetic Polypeptides. I. The Transform of Atoms on a Helix". Acta Cryst., 5, 581-586.
External links
- Fiber Diffraction — an introduction provided by Prof. K.C. Holmes, Max Planck Institute for Medical Research, Heidelberg.
Protein structure determination methods | |
|---|---|
| High resolution | X-ray crystallography | NMR | Electron crystallography |
| Medium resolution | Cryo-electron microscopy | Fiber diffraction | Mass spectrometry | SAXS |
| Spectroscopic | NMR | Circular dichroism | Absorbance | Fluorescence | Fluorescence anisotropy |
| Translational Diffusion | Analytical ultracentrifugation | Size exclusion chromatography | Light scattering | NMR |
| Rotational Diffusion | Fluorescence anisotropy | Flow birefringence | Dielectric relaxation | NMR |
| Chemical | Hydrogen-deuterium exchange | Site-directed mutagenesis | Chemical modification |
| Thermodynamic | Equilibrium unfolding |
| Computational | Protein structure prediction | Molecular docking |
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