Flunarizine
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| Image:Flunarizine structure.svg | |
| Flunarizine
| |
| Systematic (IUPAC) name | |
| 1-[bis(4-fluorophenyl)methyl]-4-cinnamyl-piperazine | |
| Identifiers | |
| CAS number | |
| ATC code | N07 |
| PubChem | |
| Chemical data | |
| Formula | C26H26F2N2 |
| Mol. mass | 404.495 |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Flunarizine is a drug classified as a calcium channel blocker. Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia. Flunarizine was discovered at Janssen Pharmaceutica in 1967.
References
- Van Nueten JM, Janssen PA., Comparative study of the effects of flunarizine and cinnarizine on smooth muscles and cardiac tissues, Arch Int Pharmacodyn Ther. 1973 Jul;204(1):37-55.
- Amery WK., Flunarizine, a calcium channel blocker: a new prophylactic drug in migraine, Headache. 1983 Mar;23(2):70-4.
Antivertigo preparations (N07C) |
|---|
| Betahistine - Cinnarizine - Flunarizine - Acetylleucine |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
