Follicular lymphoma
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| Follicular lymphoma Classification and external resources | |
| ICD-10 | C82. |
|---|---|
| ICD-9 | 202.0 |
| ICD-O: | M9690/3 |
| eMedicine | med/1362 |
| MeSH | D008224 |
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Overview
Follicular lymphoma (FL) is the most common of the indolent non-Hodgkin's lymphomas. It is defined as a lymphoma of follicle center B-cells (centrocytes and centroblasts), which has at least a partially follicular pattern. It is positive for CD10.[1]
Morphology
The tumor is composed of follicle center cells, usually a mixture of centrocytes (cleaved follicle center cells, "small cells") and centroblasts (large noncleaved follicle center cells, "large cells"). Centrocytes typically predominate; centroblasts are usually in the minority, but by definition are always present. Rare lymphomas with a follicular growth pattern consist almost entirely of centroblasts. Occasional cases may show plasmacytoid differentiation of foci of marginal zone or monocytoid B-cells.
Causes
A translocation between chromosome 14 and 18 results in the overexpression of the bcl2 gene. This overexpression causes a blockage of apoptosis, or programmed cell death. This translocation has been associated with the development of Follicular lymphoma.
Treatment
There is no consensus regarding the best treatment algorithm, but watch-and-wait policies, alkylators, anthracycline-containing regimens (eg. CHOP), rituximab, autologous and allogeneic hematopoietic stem cell transplantation have all been applied. The disease is regarded as incurable (although allogeneic stem cell transplanation may be curative, the mortality from the procedure is too high to be a first line option). The exception is localised disease, which can be cured by local irradiation. The typical pattern is one of good responses from treatment, followed by relapses some years later. Median survival is around 10 years, but the range is wide, from less than one year, to more than 20 years. Some patients may never need treatment.
References
External links
- http://www.LymphomaSurvival.com Strategies for Long-Term Survival
- Follicular Lymphoma Resource page - Patients Against Lymphoma
- Lymphoma information network
WikiDoc Research Resources for Follicular lymphoma | |
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| Cost Effectiveness of Follicular lymphoma | Cost Effectiveness of Follicular lymphoma |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
