Fosfomycin
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| Image:Fosfomycin skeletal.svg | |
| Fosfomycin
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| Systematic (IUPAC) name | |
| [(2R,3S)-3-methyloxiran-2-yl]phosphonic acid | |
| Identifiers | |
| CAS number | 78964-85-9 (tromethamine) |
| ATC code | J01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C3H7O4P |
| Mol. mass | 138.059 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 30–37% (oral, fosfomycin tromethamine); varies with food intake |
| Protein binding | Nil |
| Metabolism | Nil |
| Half life | 5.7 hours (mean) |
| Excretion | Renal and fecal, unchanged |
| Therapeutic considerations | |
| Pregnancy cat. |
B(US) |
| Legal status | |
| Routes | Oral |
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Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is indicated in the treatment of urinary tract infections. It is usually administered as fosfomycin tromethamine, trade name Monurol.
Fosfomycin is usually administered as a single dose.
See also
External links
Antibacterials for systemic use: others (J01X) | |
|---|---|
| Glycopeptide | Vancomycin (Oritavancin, Telavancin) - Teicoplanin (Dalbavancin) |
| Polymyxins | Colistin - Polymyxin B |
| Steroid antibacterials | Fusidic acid |
| Imidazole derivatives | Metronidazole - Tinidazole - Ornidazole |
| Nitrofuran derivatives | Nitrofurantoin - Nifurtoinol |
| Other | -mycin (Fosfomycin, Spectinomycin, Daptomycin, Hitachimycin) Xibornol - Clofoctol - Methenamine - Iclaprim - Mandelic acid - Nitroxoline - Linezolid |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
