Fulvestrant

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Fulvestrant
Systematic (IUPAC) name
13-methyl-7-[9-( 4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]- 7,8,9,11,12,13,14,15,16, 17-decahydro- 6H-cyclopenta[a] phenanthrene-3,17-diol
Identifiers
CAS number	129453-61-8
ATC code	L02BA03
PubChem	104741
DrugBank	APRD00654
Chemical data
Formula	C32H47F5O3S
Mol. mass	606.772 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	99%
Metabolism	?
Half life	40 days
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Intramuscular injection

WikiDoc Resources for Fulvestrant
Articles
Most recent articles on Fulvestrant Most cited articles on Fulvestrant Review articles on Fulvestrant Articles on Fulvestrant in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Fulvestrant Images of Fulvestrant Photos of Fulvestrant Podcasts & MP3s on Fulvestrant Videos on Fulvestrant
Evidence Based Medicine
Cochrane Collaboration on Fulvestrant Bandolier on Fulvestrant TRIP on Fulvestrant
Clinical Trials
Ongoing Trials on Fulvestrant at Clinical Trials.gov Trial results on Fulvestrant Clinical Trials on Fulvestrant at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Fulvestrant NICE Guidance on Fulvestrant NHS PRODIGY Guidance FDA on Fulvestrant CDC on Fulvestrant
Books
Books on Fulvestrant
News
Fulvestrant in the news Be alerted to news on Fulvestrant News trends on Fulvestrant
Commentary
Blogs on Fulvestrant
Definitions
Definitions of Fulvestrant
Patient Resources / Community
Patient resources on Fulvestrant Discussion groups on Fulvestrant Patient Handouts on Fulvestrant Directions to Hospitals Treating Fulvestrant Risk calculators and risk factors for Fulvestrant
Healthcare Provider Resources
Symptoms of Fulvestrant Causes & Risk Factors for Fulvestrant Diagnostic studies for Fulvestrant Treatment of Fulvestrant
Continuing Medical Education (CME)
CME Programs on Fulvestrant
International
Fulvestrant en Espanol Fulvestrant en Francais
Businness
Fulvestrant in the Marketplace Patents on Fulvestrant
Experimental / Informatics
List of terms related to Fulvestrant

Fulvestrant, also known as ICI 182,780, and "Faslodex" is a drug treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. It is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor.^[1] It is administered as a once-monthly injection.

Fulvestrant is marketed by AstraZeneca with the brand name Faslodex.

External links

• Faslodex package insert and prescribing information
• Faslodex

References

v • d • e WikiDoc Research Resources for Fulvestrant
Articles on Fulvestrant	Most recent articles on Fulvestrant • Most cited articles on Fulvestrant • Review articles on Fulvestrant • Articles on Fulvestrant in N Eng J Med, Lancet, BMJ
Media (Slides, Video, Images, MP3) on Fulvestrant	Powerpoint slides on Fulvestrant • Images of Fulvestrant • Photos of Fulvestrant • Podcasts & MP3s on Fulvestrant • Videos on Fulvestrant
Evidence Based Medicine Regarding Fulvestrant	Cochrane Collaboration on Fulvestrant • Bandolier on Fulvestrant • TRIP on Fulvestrant
Cost Effectiveness of Fulvestrant	Cost Effectiveness of Fulvestrant
Clinical Trials Involving Fulvestrant	Ongoing Trials on Fulvestrant at Clinical Trials.gov • Trial results on Fulvestrant • Clinical Trials on Fulvestrant at Google
Guidelines / Policies / Government Resources (FDA/CDC) Regarding Fulvestrant	US National Guidelines Clearinghouse on Fulvestrant • NICE Guidance on Fulvestrant • NHS PRODIGY Guidance • FDA on Fulvestrant • CDC on Fulvestrant
Textbook Information on Fulvestrant	Books and Textbook Information on Fulvestrant
Pharmacology Resources on Fulvestrant	Dosing of Fulvestrant • Drug interactions with Fulvestrant • Side effects of Fulvestrant • Allergic reactions to Fulvestrant • Overdose information on Fulvestrant • Carcinogenicity information on Fulvestrant • Fulvestrant in pregnancy • Pharmacokinetics of Fulvestrant •
Genetics, Pharmacogenomics, and Proteinomics of Fulvestrant	Genetics of Fulvestrant • Pharmacogenomics of Fulvestrant • Proteomics of Fulvestrant
Newstories on Fulvestrant	Fulvestrant in the news • Be alerted to news on Fulvestrant • News trends on Fulvestrant
Commentary on Fulvestrant	Blogs on Fulvestrant
Patient Resources on Fulvestrant	Patient resources on Fulvestrant • Discussion groups on Fulvestrant • Patient Handouts on Fulvestrant • Directions to Hospitals Treating Fulvestrant • Risk calculators and risk factors for Fulvestrant
Healthcare Provider Resources on Fulvestrant	Symptoms of Fulvestrant • Causes & Risk Factors for Fulvestrant • Diagnostic studies for Fulvestrant • Treatment of Fulvestrant
Continuing Medical Education (CME) Programs on Fulvestrant	CME Programs on Fulvestrant
International Resources on Fulvestrant	Fulvestrant en Espanol • Fulvestrant en Francais
Business Resources on Fulvestrant	Fulvestrant in the Marketplace • Patents on Fulvestrant
Informatics Resources on Fulvestrant	List of terms related to Fulvestrant

v • d • e Sex hormones and related agents (primarily G03, also L02, H01C) - human endogenous in CAPS
Progestogens: (receptor)	PROGESTERONE,Dienogest, Desogestrel, Drospirenone, Dydrogesterone, Ethisterone, Etonogestrel, Ethynodiol diacetate, Gestodene, Gestonorone, Levonorgestrel, Lynestrenol, Medroxyprogesterone, Megestrol, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Norgestrienone, Tibolone Selective progesterone receptor modulator: Asoprisnil, CDB-4124 Antiprogestogen: Mifepristone
Androgens: (receptor)	TESTOSTERONE, Androstanolone, Fluoxymesterone, Mesterolone, Methyltestosterone, (see also anabolic steroids) Antiandrogens: Bicalutamide, Cyproterone, Dienogest, Flutamide, Nilutamide, Spironolactone
Estrogens: (receptor)	ESTRADIOL, ESTRIOL, ESTRONE, Chlorotrianisene, Dienestrol, Diethylstilbestrol, Ethinylestradiol, Fosfestrol, Mestranol, Polyestradiol phosphate Selective estrogen receptor modulator: Afimoxifene, Arzoxifene, Bazedoxifene, Clomifene, Fulvestrant, Lasofoxifene, Raloxifene, Tamoxifen, Toremifene Aromatase inhibitor: Aminogluthetimide, Anastrozole, Atamestane, Exemestane, Formestane, Letrozole, Vorozole
Gonadotropins: (FSHR/LHCGR)	ovulation stim.: Clomifene, Urofollitropin Antigonadotropins: Danazol, Gestrinone
GnRH: (receptor)	agonist: Buserelin, Goserelin, Histrelin, Leuprorelin, Nafarelin, Triptorelin antagonist: Abarelix, Cetrorelix, Ganirelix

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .