Fundic glands

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Fundic glands
H&E stain of fundic gland polyp showing shortening of the gastric pits with cystic dilatation
Latin	glandulae gastricae
Gray's	subject #247 1166
Dorlands/Elsevier	g_06/12391406

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Overview

The fundus glands (or fundic glands, or gastric glands) are found in the body and fundus of the stomach.

They are simple tubes, two or more of which open into a single duct.

Pathology

Fundic gland polyposis is a medical syndrome where the fundus of the stomach develops many polyps.

Types of cells

Location	Name	Description	Secretion	Staining
Isthmus	mucous cells	In gastric pits.	mucus gel layer	Clear
Neck	parietal (oxyntic) cells	Between the chief cells and the basement membrane, larger oval cells, which stain deeply with eosin, are found; these cells are studded throughout the tube at intervals, giving it a beaded or varicose appearance. These are known as the parietal cells or oxyntic cells, and they are connected with the lumen by fine channels which run into their substance.	gastric acid and intrinsic factor	Acidophilic
Base	chief (zymogenic) cells	At the point where they open into the duct, which is termed the neck, the epithelium alters, and consists of short columnar or polyhedral, granular cells, which almost fill the tube, so that the lumen becomes suddenly constricted and is continued down as a very fine channel. They are known as the chief cells or central cells of the glands.	pepsinogen, rennin	Basophilic
Base	enteroendocrine (APUD) cells	-	hormones	-

Additional images

A fundus gland. A. Transverse section of gland.

Layers of stomach wall

External links

• gastric+glands at eMedicine Dictionary
• Histology at OU 50_02 - "Fundic stomach"
• Organology at UC Davis Digestive/mammal/stomach4/stomach2 - "Mammal, ruminant stomach (LM, High)"
• Histology at BU 11301ooa - "Digestive System: Alimentary Canal - fundic stomach"
• Veterinary Histology at vt.edu
• MedEd at Loyola Histo/frames/Histo18.html - see slide #42

This article was originally based on an entry from a public domain edition of Gray's Anatomy. As such, some of the information contained herein may be outdated. Please edit the article if this is the case, and feel free to remove this notice when it is no longer relevant.

v • d • e Anatomy of torso, digestive system: Gastrointestinal tract
Upper GI: to stomach	Mouth • Pharynx (nasopharynx, oropharynx, hypopharynx) • Esophagus • Crop
Upper GI: stomach	rugae - gastric pits - cardia/gland - fundus/gland - pylorus/gland - pyloric antrum - pyloric canal - greater curvature - lesser curvature - angular incisure
Lower GI: intestines	Small intestine: Duodenum (Suspensory muscle, Major duodenal papilla, Minor duodenal papilla) • Duodenojejunal flexure • Jejunum • Ileum • continuous (intestinal villus, crypts of Lieberkühn, circular folds) Junction: Vermiform appendix • Ileocecal valve Large intestine: Cecum • Colon (ascending colon, hepatic flexure, transverse colon, splenic flexure, descending colon, sigmoid colon) • continuous (taenia coli, haustra, epiploic appendix)
Lower GI: termination	Rectum: Houston valve • rectal ampulla • pectinate line Anal canal: anal valves • anal sinuses • anal columns • Hilton's white line Anus: Sphincter ani internus muscle • Sphincter ani externus muscle
Lower GI: lymph	GALT: Peyer's patches (M cells)

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Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .