Gastric inhibitory polypeptide receptor

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Gastric inhibitory polypeptide receptor
Identifiers
Symbol(s) GIPR; MGC126722
External IDs OMIM: 137241 MGI: 1352753 Homologene: 20081
RNA expression pattern

Image:PBB GE GIPR 208105 at tn.png

More reference expression data

Orthologs
Human Mouse
Entrez 2696 381853
Ensembl ENSG00000010310 ENSMUSG00000030406
Uniprot P48546 na
Refseq NM_000164 (mRNA)
NP_000155 (protein) 		XM_133238 (mRNA)
XP_133238 (protein)
Location Chr 19: 50.86 - 50.88 Mb Chr 7: 18.32 - 18.32 Mb
Pubmed search [1] [2]

Gastric inhibitory polypeptide receptors (GIPRs) are seven-transmembrane proteins found on beta-cells in the pancreas.[1][1]

They bind gastric inhibitory polypeptide.

References

Further reading

  • Yamada Y, Seino Y (2005). "Physiology of GIP--a lesson from GIP receptor knockout mice.". Horm. Metab. Res. 36 (11-12): 771-4. doi:10.1055/s-2004-826162. PMID 15655707.
  • Stoffel M, Fernald AA, Le Beau MM, Bell GI (1996). "Assignment of the gastric inhibitory polypeptide receptor gene (GIPR) to chromosome bands 19q13.2-q13.3 by fluorescence in situ hybridization.". Genomics 28 (3): 607-9. doi:10.1006/geno.1995.1203. PMID 7490109.
  • Gremlich S, Porret A, Hani EH, et al. (1995). "Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor.". Diabetes 44 (10): 1202-8. PMID 7556958.
  • Volz A, Göke R, Lankat-Buttgereit B, et al. (1995). "Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma.". FEBS Lett. 373 (1): 23-9. PMID 7589426.
  • Usdin TB, Mezey E, Button DC, et al. (1994). "Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain.". Endocrinology 133 (6): 2861-70. PMID 8243312.
  • Yamada Y, Hayami T, Nakamura K, et al. (1996). "Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA.". Genomics 29 (3): 773-6. doi:10.1006/geno.1995.9937. PMID 8575774.
  • Gallwitz B, Witt M, Morys-Wortmann C, et al. (1997). "GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1.". Regul. Pept. 63 (1): 17-22. PMID 8795084.
  • N'Diaye N, Tremblay J, Hamet P, et al. (1998). "Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushing's syndrome.". J. Clin. Endocrinol. Metab. 83 (8): 2781-5. PMID 9709947.
  • Tseng CC, Zhang XY (2000). "Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling.". Endocrinology 141 (3): 947-52. PMID 10698169.
  • Bollag RJ, Zhong Q, Phillips P, et al. (2000). "Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors.". Endocrinology 141 (3): 1228-35. PMID 10698200.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Baldacchino V, Oble S, Hamet P, et al. (2003). "Partial characterisation of the 5' flanking region of the human GIP receptor (GIPR) gene.". Endocr. Res. 28 (4): 577. PMID 12530665.
  • Antonini SR, N'Diaye N, Hamet P, et al. (2003). "Analysis of the putative promoter region of the GIP receptor gene (GIPR) in GIP-dependent Cushing's syndrome (CS).". Endocr. Res. 28 (4): 755-6. PMID 12530694.
  • Manhart S, Hinke SA, McIntosh CH, et al. (2003). "Structure-function analysis of a series of novel GIP analogues containing different helical length linkers.". Biochemistry 42 (10): 3081-8. doi:10.1021/bi026868e. PMID 12627975.
  • Ding KH, Zhong Q, Isales CM (2003). "Glucose-dependent insulinotropic peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1.". Am. J. Physiol. Endocrinol. Metab. 285 (2): E390-6. doi:10.1152/ajpendo.00509.2002. PMID 12721154.
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.
  • Hansotia T, Baggio LL, Delmeire D, et al. (2004). "Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors.". Diabetes 53 (5): 1326-35. PMID 15111503.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
  • Baldacchino V, Oble S, Hamet P, et al. (2005). "The Sp transcription factor family is involved in the cellular expression of the human GIP-R gene promoter.". Endocr. Res. 30 (4): 805-6. PMID 15666829.

External links

Template:Membrane-protein-stub

v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin likeAcetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - Neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin likeBrain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)
Class C: Metabotropic glutamate / pheromoneCalcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / SmoothenedFrizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened


Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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