GCM2
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| Glial cells missing homolog 2 (Drosophila)
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| Identifiers | ||||||||||||||
| Symbol(s) | GCM2; GCMB; hGCMb | |||||||||||||
| External IDs | OMIM: 603716 MGI: 1861438 Homologene: 3490 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 9247 | 107889 | ||||||||||||
| Ensembl | ENSG00000124827 | ENSMUSG00000021362 | ||||||||||||
| Uniprot | O75603 | Q2TB03 | ||||||||||||
| Refseq | NM_004752 (mRNA) NP_004743 (protein) | NM_008104 (mRNA) NP_032130 (protein) | ||||||||||||
| Location | Chr 6: 10.98 - 10.99 Mb | Chr 13: 41.11 - 41.12 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Glial cells missing homolog 2 (Drosophila), also known as GCM2, is a human gene.[1]
The Drosophila 'glial cells missing' (gcm) gene is thought to act as a binary switch between neuronal and glial cell determination. The gcm protein and mammalian gcm homologs contain a conserved N-terminal gcm motif that has DNA-binding activity. See GCM1 (MIM 603715).[supplied by OMIM][1]
References
Further reading
- Kanemura Y, Hiraga S, Arita N, et al. (1999). "Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene.". FEBS Lett. 442 (2-3): 151-6. PMID 9928992.
- Kammerer M, Pirola B, Giglio S, Giangrande A (1999). "GCMB, a second human homolog of the fly glide/gcm gene.". Cytogenet. Cell Genet. 84 (1-2): 43-7. PMID 10343099.
- Correa P, Akerström G, Westin G (2002). "Underexpression of Gcm2, a master regulatory gene of parathyroid gland development, in adenomas of primary hyperparathyroidism.". Clin. Endocrinol. (Oxf) 57 (4): 501-5. PMID 12354132.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
- Maret A, Bourdeau I, Ding C, et al. (2004). "Expression of GCMB by intrathymic parathyroid hormone-secreting adenomas indicates their parathyroid cell origin.". J. Clin. Endocrinol. Metab. 89 (1): 8-12. PMID 14715818.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
- Kebebew E, Peng M, Wong MG, et al. (2005). "GCMB gene, a master regulator of parathyroid gland development, expression, and regulation in hyperparathyroidism.". Surgery 136 (6): 1261-6. doi:10.1016/j.surg.2004.06.056. PMID 15657585.
- Thomée C, Schubert SW, Parma J, et al. (2005). "GCMB mutation in familial isolated hypoparathyroidism with residual secretion of parathyroid hormone.". J. Clin. Endocrinol. Metab. 90 (5): 2487-92. doi:10.1210/jc.2004-2450. PMID 15728199.
- Baumber L, Tufarelli C, Patel S, et al. (2006). "Identification of a novel mutation disrupting the DNA binding activity of GCM2 in autosomal recessive familial isolated hypoparathyroidism.". J. Med. Genet. 42 (5): 443-8. doi:10.1136/jmg.2004.026898. PMID 15863676.
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
