Gla domain
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| Anchoring of Coagulation factor VIIa to the membrane through its GLA domain | ||
| Identifiers | ||
| Symbol | Gla | |
| Pfam | PF00594 | |
| InterPro | IPR000294 | |
| PROSITE | PDOC00011 | |
| SCOP | 1cfi | |
| OPM family | 97 | |
| OPM protein | 1pfx | |
| Available PDB structures:
1q8hA:6-47 1q3mA:57-98 1vzmB:53-93 1nl1A:49-90 2spt :49-90 1nl2A:49-90 2pf1 :79-90 1nl8L:45-86 1p0sL:45-86 1whf :45-86 1whe :45-86 1iodG:45-84 1j34C:6-46 1j35C:6-46 1pfxL:8-48 1cfi :52-93 1cfh :52-93 1mgx :52-93 1nl0G:52-91 1lqvC:47-75 1wv7L:65-106 1wqvL:65-106 1wssL:65-106 1w0yL:65-106 1z6jL:65-106 1fakL:65-106 1wunL:65-106 1wtgL:65-106 1danL:65-106 | ||
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain is a protein domain that contains post-translational modifications of many glutamate residues by vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla). The Gla residues are responsible for the high-affinity binding of calcium ions [1][1].
The GLA domain is responsible for the high-affinity binding of calcium ions. It starts at the N-terminal extremity of the mature form of proteins and ends with a conserved aromatic residue; a conserved Gla-x(3)-Gla-x-Cys motif[1] is found in the middle of the domain which seems to be important for substrate recognition by the carboxylase.
The 3D structures of several Gla domains have been solved[1][1]. Calcium ions induce conformational changes in the Gla domain and are necessary for the Gla domain to fold properly. A common structural feature of functional Gla domains is the clustering of N-terminal hydrophobic residues into a hydrophobic patch that mediates interaction with the cell surface membrane[1].
Subfamilies
- Coagulation factor, Gla region InterPro IPR002383
Human proteins containing this domain
BGLAP; F10; F2; F7; F9; GAS6; MGP; PROC; PROS1; PROZ; PRRG1; PRRG2; PRRG3; PRRG4;
References
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
